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HIV reservoirs are dominated by genetically younger and clonally enriched proviruses.
Kinloch NN, Shahid A, Dong W, Kirkby D, Jones BR, Beelen CJ, MacMillan D, Lee GQ, Mota TM, Sudderuddin H, Barad E, Harris M, Brumme CJ, Jones RB, Brockman MA, Joy JB, Brumme ZL. Kinloch NN, et al. Among authors: mota tm. mBio. 2023 Nov 16;14(6):e0241723. doi: 10.1128/mbio.02417-23. Online ahead of print. mBio. 2023. PMID: 37971267 Free PMC article.
HIV reservoirs are dominated by genetically younger and clonally enriched proviruses.
Kinloch NN, Shahid A, Dong W, Kirkby D, Jones BR, Beelen CJ, MacMillan D, Lee GQ, Mota TM, Sudderuddin H, Barad E, Harris M, Brumme CJ, Jones RB, Brockman MA, Joy JB, Brumme ZL. Kinloch NN, et al. Among authors: mota tm. bioRxiv [Preprint]. 2023 Apr 13:2023.04.12.536611. doi: 10.1101/2023.04.12.536611. bioRxiv. 2023. PMID: 37090500 Free PMC article. Updated. Preprint.
A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies.
McCann CD, van Dorp CH, Danesh A, Ward AR, Dilling TR, Mota TM, Zale E, Stevenson EM, Patel S, Brumme CJ, Dong W, Jones DS, Andresen TL, Walker BD, Brumme ZL, Bollard CM, Perelson AS, Irvine DJ, Jones RB. McCann CD, et al. Among authors: mota tm. J Exp Med. 2021 Jul 5;218(7):e20201908. doi: 10.1084/jem.20201908. Epub 2021 May 14. J Exp Med. 2021. PMID: 33988715 Free PMC article.
Author Correction: HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA).
Kinloch NN, Ren Y, Alberto WDC, Dong W, Khadka P, Huang SH, Mota TM, Wilson A, Shahid A, Kirkby D, Harris M, Kovacs C, Benko E, Ostrowski MA, Del Rio Estrada PM, Wimpelberg A, Cannon C, Hardy WD, MacLaren L, Goldstein H, Brumme CJ, Lee GQ, Lynch RM, Brumme ZL, Jones RB. Kinloch NN, et al. Among authors: mota tm. Nat Commun. 2021 May 13;12(1):2958. doi: 10.1038/s41467-021-23515-z. Nat Commun. 2021. PMID: 33986282 Free PMC article. No abstract available.
Selective BCL-XL Antagonists Eliminate Infected Cells from a Primary-Cell Model of HIV Latency but Not from Ex Vivo Reservoirs.
Ren Y, Huang SH, Macedo AB, Ward AR, Alberto WDC, Klevorn T, Leyre L, Copertino DC, Mota TM, Chan D, Truong R, Rohwetter T, Zumbo P, Dündar F, Betel D, Kovacs C, Benko E, Bosque A, Jones RB. Ren Y, et al. Among authors: mota tm. J Virol. 2021 Jul 12;95(15):e0242520. doi: 10.1128/JVI.02425-20. Epub 2021 Jul 12. J Virol. 2021. PMID: 33980597 Free PMC article.
HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA).
Kinloch NN, Ren Y, Conce Alberto WD, Dong W, Khadka P, Huang SH, Mota TM, Wilson A, Shahid A, Kirkby D, Harris M, Kovacs C, Benko E, Ostrowski MA, Del Rio Estrada PM, Wimpelberg A, Cannon C, Hardy WD, MacLaren L, Goldstein H, Brumme CJ, Lee GQ, Lynch RM, Brumme ZL, Jones RB. Kinloch NN, et al. Among authors: mota tm. Nat Commun. 2021 Jan 8;12(1):165. doi: 10.1038/s41467-020-20442-3. Nat Commun. 2021. PMID: 33420062 Free PMC article.
HIV-specific T cell responses reflect substantive in vivo interactions with antigen despite long-term therapy.
Stevenson EM, Ward AR, Truong R, Thomas AS, Huang SH, Dilling TR, Terry S, Bui JK, Mota TM, Danesh A, Lee GQ, Gramatica A, Khadka P, Alberto WDC, Gandhi RT, McMahon DK, Lalama CM, Bosch RJ, Macatangay B, Cyktor JC, Eron JJ, Mellors JW, Jones RB; AIDS Clinical Trials Group A5321 Team. Stevenson EM, et al. Among authors: mota tm. JCI Insight. 2021 Feb 8;6(3):e142640. doi: 10.1172/jci.insight.142640. JCI Insight. 2021. PMID: 33400687 Free PMC article.
Immunological approaches to HIV cure.
Ward AR, Mota TM, Jones RB. Ward AR, et al. Among authors: mota tm. Semin Immunol. 2021 Jan;51:101412. doi: 10.1016/j.smim.2020.101412. Epub 2020 Sep 24. Semin Immunol. 2021. PMID: 32981836 Free article. Review.
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