Morton JD - Search Results

1

Tripeptide analogues of MG132 as protease inhibitors.

Pehere AD, Nguyen S, Garlick SK, Wilson DW, Hudson I, Sykes MJ, Morton JD, Abell AD. Pehere AD, et al. Among authors: morton jd. Bioorg Med Chem. 2019 Jan 15;27(2):436-441. doi: 10.1016/j.bmc.2018.12.022. Epub 2018 Dec 14. Bioorg Med Chem. 2019. PMID: 30581047

2

Investigation into the P3 binding domain of m-calpain using photoswitchable diazo- and triazene-dipeptide aldehydes: new anticataract agents.

Abell AD, Jones MA, Neffe AT, Aitken SG, Cain TP, Payne RJ, McNabb SB, Coxon JM, Stuart BG, Pearson D, Lee HY, Morton JD. Abell AD, et al. Among authors: morton jd. J Med Chem. 2007 Jun 14;50(12):2916-20. doi: 10.1021/jm061455n. Epub 2007 May 12. J Med Chem. 2007. PMID: 17497840

3

Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors.

Jones MA, Morton JD, Coxon JM, McNabb SB, Lee HY, Aitken SG, Mehrtens JM, Robertson LJ, Neffe AT, Miyamoto S, Bickerstaffe R, Gately K, Wood JM, Abell AD. Jones MA, et al. Among authors: morton jd. Bioorg Med Chem. 2008 Jul 15;16(14):6911-23. doi: 10.1016/j.bmc.2008.05.048. Epub 2008 May 27. Bioorg Med Chem. 2008. PMID: 18571418

4

Molecular modeling, synthesis, and biological evaluation of macrocyclic calpain inhibitors.

Abell AD, Jones MA, Coxon JM, Morton JD, Aitken SG, McNabb SB, Lee HY, Mehrtens JM, Alexander NA, Stuart BG, Neffe AT, Bickerstaffe R. Abell AD, et al. Among authors: morton jd. Angew Chem Int Ed Engl. 2009;48(8):1455-8. doi: 10.1002/anie.200805014. Angew Chem Int Ed Engl. 2009. PMID: 19145612

5

Evaluation of a novel calpain inhibitor as a treatment for cataract.

Lee HY, Morton JD, Robertson LJ, McDermott JD, Bickerstaffe R, Abell AD, Jones MA, Mehrtens JM, Coxon JM. Lee HY, et al. Among authors: morton jd. Clin Exp Ophthalmol. 2008 Dec;36(9):852-60. doi: 10.1111/j.1442-9071.2009.01925.x. Clin Exp Ophthalmol. 2008. PMID: 19278481

6

Molecular modeling: a search for a calpain inhibitor as a new treatment for cataractogenesis.

Stuart BG, Coxon JM, Morton JD, Abell AD, McDonald DQ, Aitken SG, Jones MA, Bickerstaffe R. Stuart BG, et al. Among authors: morton jd. J Med Chem. 2011 Nov 10;54(21):7503-22. doi: 10.1021/jm200471r. Epub 2011 Oct 10. J Med Chem. 2011. PMID: 21955158

7

New tripeptide-based macrocyclic calpain inhibitors formed by N-alkylation of histidine.

Chen H, Jiao W, Jones MA, Coxon JM, Morton JD, Bickerstaffe R, Pehere AD, Zvarec O, Abell AD. Chen H, et al. Among authors: morton jd. Chem Biodivers. 2012 Nov;9(11):2473-84. doi: 10.1002/cbdv.201200320. Chem Biodivers. 2012. PMID: 23161629

8

A macrocyclic calpain inhibitor slows the development of inherited cortical cataracts in a sheep model.

Morton JD, Lee HY, McDermott JD, Robertson LJ, Bickerstaffe R, Jones MA, Coxon JM, Abell AD. Morton JD, et al. Invest Ophthalmol Vis Sci. 2013 Jan 14;54(1):389-95. doi: 10.1167/iovs.12-11088. Invest Ophthalmol Vis Sci. 2013. PMID: 23211821

9

Calpain may contribute to hereditary cataract formation in sheep.

Robertson LJ, Morton JD, Yamaguchi M, Bickerstaffe R, Shearer TR, Azuma M. Robertson LJ, et al. Among authors: morton jd. Invest Ophthalmol Vis Sci. 2005 Dec;46(12):4634-40. doi: 10.1167/iovs.04-1291. Invest Ophthalmol Vis Sci. 2005. PMID: 16303960

10

Intermuscular variation in tenderness: association with the ubiquitous and muscle-specific calpains.

Ilian MA, Morton JD, Kent MP, Le Couteur CE, Hickford J, Cowley R, Bickerstaffe R. Ilian MA, et al. Among authors: morton jd. J Anim Sci. 2001 Jan;79(1):122-32. doi: 10.2527/2001.791122x. J Anim Sci. 2001. PMID: 11204692

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