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A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.
Mortelecque J, Zejneli O, Bégard S, Simões MC, ElHajjar L, Nguyen M, Cantrelle FX, Hanoulle X, Rain JC, Colin M, Gomes CM, Buée L, Landrieu I, Danis C, Dupré E. Mortelecque J, et al. J Biol Chem. 2024 Apr;300(4):107163. doi: 10.1016/j.jbc.2024.107163. Epub 2024 Mar 12. J Biol Chem. 2024. PMID: 38484799 Free PMC article.
Development of Receptor for Advanced Glycation End Products (RAGE) ligands through target directed dynamic combinatorial chemistry: a novel class of possible antagonists.
Dascalu AE, Furman C, Landrieu I, Cantrelle FX, Mortelecque J, Grolaux G, Gillery P, Tessier F, Lipka E, Billamboz M, Boulanger E, Ghinet A. Dascalu AE, et al. Among authors: mortelecque j. Chemistry. 2024 Apr 5;30(20):e202303255. doi: 10.1002/chem.202303255. Epub 2024 Feb 20. Chemistry. 2024. PMID: 38317623
Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.
Danis C, Dupré E, Zejneli O, Caillierez R, Arrial A, Bégard S, Mortelecque J, Eddarkaoui S, Loyens A, Cantrelle FX, Hanoulle X, Rain JC, Colin M, Buée L, Landrieu I. Danis C, et al. Among authors: mortelecque j. Mol Ther. 2022 Apr 6;30(4):1484-1499. doi: 10.1016/j.ymthe.2022.01.009. Epub 2022 Jan 7. Mol Ther. 2022. PMID: 35007758 Free PMC article.