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Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer.
Sharma S, Chung CY, Uryu S, Petrovic J, Cao J, Rickard A, Nady N, Greasley S, Johnson E, Brodsky O, Khan S, Wang H, Wang Z, Zhang Y, Tsaparikos K, Chen L, Mazurek A, Lapek J, Kung PP, Sutton S, Richardson PF, Greenwald EC, Yamazaki S, Jones R, Maegley KA, Bingham P, Lam H, Stupple AE, Kamal A, Chueh A, Cuzzupe A, Morrow BJ, Ren B, Carrasco-Pozo C, Tan CW, Bhuva DD, Allan E, Surgenor E, Vaillant F, Pehlivanoglu H, Falk H, Whittle JR, Newman J, Cursons J, Doherty JP, White KL, MacPherson L, Devlin M, Dennis ML, Hattarki MK, De Silva M, Camerino MA, Butler MS, Dolezal O, Pilling P, Foitzik R, Stupple PA, Lagiakos HR, Walker SR, Hediyeh-Zadeh S, Nuttall S, Spall SK, Charman SA, Connor T, Peat TS, Avery VM, Bozikis YE, Yang Y, Zhang M, Monahan BJ, Voss AK, Thomas T, Street IP, Dawson SJ, Dawson MA, Lindeman GJ, Davis MJ, Visvader JE, Paul TA. Sharma S, et al. Among authors: morrow bj. Cell Chem Biol. 2023 Oct 19;30(10):1191-1210.e20. doi: 10.1016/j.chembiol.2023.07.005. Epub 2023 Aug 8. Cell Chem Biol. 2023. PMID: 37557181 Free article.
Fragment screening for a protein-protein interaction inhibitor to WDR5.
Dennis ML, Morrow BJ, Dolezal O, Cuzzupe AN, Stupple AE, Newman J, Bentley J, Hattarki M, Nuttall SD, Foitzik RC, Street IP, Stupple PA, Monahan BJ, Peat TS. Dennis ML, et al. Among authors: morrow bj. Struct Dyn. 2019 Nov 14;6(6):064701. doi: 10.1063/1.5122849. eCollection 2019 Nov. Struct Dyn. 2019. PMID: 31768400 Free PMC article.
Pro-fluorescent mitochondria-targeted real-time responsive redox probes synthesised from carboxy isoindoline nitroxides: Sensitive probes of mitochondrial redox status in cells.
Chong KL, Chalmers BA, Cullen JK, Kaur A, Kolanowski JL, Morrow BJ, Fairfull-Smith KE, Lavin MJ, Barnett NL, New EJ, Murphy MP, Bottle SE. Chong KL, et al. Among authors: morrow bj. Free Radic Biol Med. 2018 Nov 20;128:97-110. doi: 10.1016/j.freeradbiomed.2018.03.008. Epub 2018 Mar 19. Free Radic Biol Med. 2018. PMID: 29567391
Antistaphylococcal activities of the new fluoroquinolone JNJ-Q2.
Morrow BJ, Abbanat D, Baum EZ, Crespo-Carbone SM, Davies TA, He W, Shang W, Queenan AM, Lynch AS. Morrow BJ, et al. Antimicrob Agents Chemother. 2011 Dec;55(12):5512-21. doi: 10.1128/AAC.00470-11. Epub 2011 Sep 12. Antimicrob Agents Chemother. 2011. PMID: 21911562 Free PMC article.
26 results