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The aberrant epigenome of DNMT3B-mutated ICF1 patient iPSCs is amenable to correction, with the exception of a subset of regions with H3K4me3- and/or CTCF-based epigenetic memory.
Poondi Krishnan V, Morone B, Toubiana S, Krzak M, Fioriniello S, Della Ragione F, Strazzullo M, Angelini C, Selig S, Matarazzo MR. Poondi Krishnan V, et al. Among authors: morone b. Genome Res. 2023 Feb;33(2):169-183. doi: 10.1101/gr.276986.122. Epub 2023 Feb 24. Genome Res. 2023. PMID: 36828588 Free PMC article.