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Enzymatic Late-Stage Halogenation of Peptides.
Chembiochem. 2023 Jan 3;24(1):e202200569. doi: 10.1002/cbic.202200569. Epub 2022 Nov 23.
Chembiochem. 2023.
PMID: 36259362
Free PMC article.
Structure-based switch of regioselectivity in the flavin-dependent tryptophan 6-halogenase Thal.
Moritzer AC, Minges H, Prior T, Frese M, Sewald N, Niemann HH.
Moritzer AC, et al.
J Biol Chem. 2019 Feb 15;294(7):2529-2542. doi: 10.1074/jbc.RA118.005393. Epub 2018 Dec 17.
J Biol Chem. 2019.
PMID: 30559288
Free PMC article.
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Binding of FAD and tryptophan to the tryptophan 6-halogenase Thal is negatively coupled.
Moritzer AC, Niemann HH.
Moritzer AC, et al.
Protein Sci. 2019 Dec;28(12):2112-2118. doi: 10.1002/pro.3739. Epub 2019 Oct 21.
Protein Sci. 2019.
PMID: 31589794
Free PMC article.
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Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds.
Sainas S, Pippione AC, Giorgis M, Lupino E, Goyal P, Ramondetti C, Buccinnà B, Piccinini M, Braga RC, Andrade CH, Andersson M, Moritzer AC, Friemann R, Mensa S, Al-Kadaraghi S, Boschi D, Lolli ML.
Sainas S, et al. Among authors: moritzer ac.
Eur J Med Chem. 2017 Mar 31;129:287-302. doi: 10.1016/j.ejmech.2017.02.017. Epub 2017 Feb 14.
Eur J Med Chem. 2017.
PMID: 28235702
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