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Design, synthesis and biological evaluation of 2-pyrrolone derivatives as radioprotectors.
Satoh H, Ochi S, Mizuno K, Saga Y, Ujita S, Toyoda M, Nishiyama Y, Tada K, Matsushita Y, Deguchi Y, Suzuki K, Tanaka Y, Ueda H, Inaba T, Hosoi Y, Morita A, Aoki S. Satoh H, et al. Among authors: morita a. Bioorg Med Chem. 2022 Aug 1;67:116764. doi: 10.1016/j.bmc.2022.116764. Epub 2022 May 9. Bioorg Med Chem. 2022. PMID: 35635928
Evaluation of zinc (II) chelators for inhibiting p53-mediated apoptosis.
Morita A, Ariyasu S, Ohya S, Takahashi I, Wang B, Tanaka K, Uchida T, Okazaki H, Hanaya K, Enomoto A, Nenoi M, Ikekita M, Aoki S, Hosoi Y. Morita A, et al. Oncotarget. 2013 Dec;4(12):2439-50. doi: 10.18632/oncotarget.1535. Oncotarget. 2013. PMID: 24280450 Free PMC article.
A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist.
Morita A, Takahashi I, Sasatani M, Aoki S, Wang B, Ariyasu S, Tanaka K, Yamaguchi T, Sawa A, Nishi Y, Teraoka T, Ujita S, Kawate Y, Yanagawa C, Tanimoto K, Enomoto A, Nenoi M, Kamiya K, Nagata Y, Hosoi Y, Inaba T. Morita A, et al. Mol Cancer Ther. 2018 Feb;17(2):432-442. doi: 10.1158/1535-7163.MCT-16-0554. Epub 2017 Sep 22. Mol Cancer Ther. 2018. PMID: 28939557
Evaluation of sodium orthovanadate as a radioprotective agent under total-body irradiation and partial-body irradiation conditions in mice.
Nishiyama Y, Morita A, Wang B, Sakai T, Ramadhani D, Satoh H, Tanaka K, Sasatani M, Ochi S, Tominaga M, Ikushima H, Ueno J, Nenoi M, Aoki S. Nishiyama Y, et al. Among authors: morita a. Int J Radiat Biol. 2021;97(9):1241-1251. doi: 10.1080/09553002.2021.1941377. Epub 2021 Jul 1. Int J Radiat Biol. 2021. PMID: 34125648
AS-2, a novel inhibitor of p53-dependent apoptosis, prevents apoptotic mitochondrial dysfunction in a transcription-independent manner and protects mice from a lethal dose of ionizing radiation.
Morita A, Ariyasu S, Wang B, Asanuma T, Onoda T, Sawa A, Tanaka K, Takahashi I, Togami S, Nenoi M, Inaba T, Aoki S. Morita A, et al. Biochem Biophys Res Commun. 2014 Aug 8;450(4):1498-504. doi: 10.1016/j.bbrc.2014.07.037. Epub 2014 Jul 12. Biochem Biophys Res Commun. 2014. PMID: 25026551
1,594 results