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Sodium orthovanadate inhibits p53-mediated apoptosis.
Morita A, Yamamoto S, Wang B, Tanaka K, Suzuki N, Aoki S, Ito A, Nanao T, Ohya S, Yoshino M, Zhu J, Enomoto A, Matsumoto Y, Funatsu O, Hosoi Y, Ikekita M. Morita A, et al. Cancer Res. 2010 Jan 1;70(1):257-65. doi: 10.1158/0008-5472.CAN-08-3771. Cancer Res. 2010. PMID: 20048077
Evaluation of zinc (II) chelators for inhibiting p53-mediated apoptosis.
Morita A, Ariyasu S, Ohya S, Takahashi I, Wang B, Tanaka K, Uchida T, Okazaki H, Hanaya K, Enomoto A, Nenoi M, Ikekita M, Aoki S, Hosoi Y. Morita A, et al. Oncotarget. 2013 Dec;4(12):2439-50. doi: 10.18632/oncotarget.1535. Oncotarget. 2013. PMID: 24280450 Free PMC article.
AS-2, a novel inhibitor of p53-dependent apoptosis, prevents apoptotic mitochondrial dysfunction in a transcription-independent manner and protects mice from a lethal dose of ionizing radiation.
Morita A, Ariyasu S, Wang B, Asanuma T, Onoda T, Sawa A, Tanaka K, Takahashi I, Togami S, Nenoi M, Inaba T, Aoki S. Morita A, et al. Biochem Biophys Res Commun. 2014 Aug 8;450(4):1498-504. doi: 10.1016/j.bbrc.2014.07.037. Epub 2014 Jul 12. Biochem Biophys Res Commun. 2014. PMID: 25026551
A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist.
Morita A, Takahashi I, Sasatani M, Aoki S, Wang B, Ariyasu S, Tanaka K, Yamaguchi T, Sawa A, Nishi Y, Teraoka T, Ujita S, Kawate Y, Yanagawa C, Tanimoto K, Enomoto A, Nenoi M, Kamiya K, Nagata Y, Hosoi Y, Inaba T. Morita A, et al. Mol Cancer Ther. 2018 Feb;17(2):432-442. doi: 10.1158/1535-7163.MCT-16-0554. Epub 2017 Sep 22. Mol Cancer Ther. 2018. PMID: 28939557
1,590 results