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Phosphorylation of KRAB-associated protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by nuclear tyrosine kinases inhibits the association of KAP1 and heterochromatin protein 1α (HP1α) with heterochromatin.
Kubota S, Fukumoto Y, Aoyama K, Ishibashi K, Yuki R, Morinaga T, Honda T, Yamaguchi N, Kuga T, Tomonaga T, Yamaguchi N. Kubota S, et al. Among authors: morinaga t. J Biol Chem. 2013 Jun 14;288(24):17871-83. doi: 10.1074/jbc.M112.437756. Epub 2013 May 4. J Biol Chem. 2013. PMID: 23645696 Free PMC article.
Expression of p53 synergistically augments caspases-mediated apoptosis induced by replication-competent adenoviruses in pancreatic carcinoma cells.
Takei Y, Okamoto S, Kawamura K, Jiang Y, Morinaga T, Shingyoji M, Sekine I, Kubo S, Tada Y, Tatsumi K, Shimada H, Hiroshima K, Yamaguchi N, Tagawa M. Takei Y, et al. Among authors: morinaga t. Cancer Gene Ther. 2015 Sep;22(9):445-53. doi: 10.1038/cgt.2015.33. Epub 2015 Aug 7. Cancer Gene Ther. 2015. PMID: 26251031
Replication-competent adenoviruses with the type 35-derived fiber-knob region achieve reactive oxygen species-dependent cytotoxicity and produce greater toxicity than those with the type 5-derived region in pancreatic carcinoma.
Yamauchi S, Kawamura K, Okamoto S, Morinaga T, Jiang Y, Shingyoji M, Sekine I, Kubo S, Tada Y, Tatsumi K, Shimada H, Hiroshima K, Tagawa M. Yamauchi S, et al. Among authors: morinaga t. Apoptosis. 2015 Dec;20(12):1587-98. doi: 10.1007/s10495-015-1171-8. Apoptosis. 2015. PMID: 26373551
296 results