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Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
Morimoto S, Takahashi S, Ito D, Daté Y, Okada K, Kato C, Nakamura S, Ozawa F, Chyi CM, Nishiyama A, Suzuki N, Fujimori K, Kondo T, Takao M, Hirai M, Kabe Y, Suematsu M, Jinzaki M, Aoki M, Fujiki Y, Sato Y, Suzuki N, Nakahara J; Pooled Resource Open-Access ALS Clinical Trials Consortium; Okano H. Morimoto S, et al. Cell Stem Cell. 2023 Jun 1;30(6):766-780.e9. doi: 10.1016/j.stem.2023.04.017. Cell Stem Cell. 2023. PMID: 37267913 Free article. Clinical Trial.
Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.
Akiyama T, Suzuki N, Ishikawa M, Fujimori K, Sone T, Kawada J, Funayama R, Fujishima F, Mitsuzawa S, Ikeda K, Ono H, Shijo T, Osana S, Shirota M, Nakagawa T, Kitajima Y, Nishiyama A, Izumi R, Morimoto S, Okada Y, Kamei T, Nishida M, Nogami M, Kaneda S, Ikeuchi Y, Mitsuhashi H, Nakayama K, Fujii T, Warita H, Okano H, Aoki M. Akiyama T, et al. Among authors: morimoto s. EBioMedicine. 2019 Jul;45:362-378. doi: 10.1016/j.ebiom.2019.06.013. Epub 2019 Jun 29. EBioMedicine. 2019. PMID: 31262712 Free PMC article.
Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis - Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial).
Morimoto S, Takahashi S, Fukushima K, Saya H, Suzuki N, Aoki M, Okano H, Nakahara J. Morimoto S, et al. Regen Ther. 2019 Jul 26;11:143-166. doi: 10.1016/j.reth.2019.07.002. eCollection 2019 Dec. Regen Ther. 2019. PMID: 31384636 Free PMC article.
[Ropinirole Hydrochloride for ALS].
Takahashi S, Morimoto S, Fukushima K, Nakahara J, Okano H. Takahashi S, et al. Among authors: morimoto s. Brain Nerve. 2019 Nov;71(11):1279-1288. doi: 10.11477/mf.1416201438. Brain Nerve. 2019. PMID: 31722314 Clinical Trial. Japanese.
Ropinirole, a New ALS Drug Candidate Developed Using iPSCs.
Okano H, Yasuda D, Fujimori K, Morimoto S, Takahashi S. Okano H, et al. Among authors: morimoto s. Trends Pharmacol Sci. 2020 Feb;41(2):99-109. doi: 10.1016/j.tips.2019.12.002. Epub 2020 Jan 8. Trends Pharmacol Sci. 2020. PMID: 31926602 Free article. Review.
2,082 results