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A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway.
Elsasser S, Elia LP, Morimoto RI, Powers ET, Finley D, Costa B, Budron M, Tokuno Z, Wang S, Iyer RG, Barth B, Mockler E, Finkbeiner S, Gestwicki JE, Richardson RAK, Stoeger T, Tan EP, Xiao Q, Cole CM, Massey LA, Garza D, Kelly JW, Rainbolt TK, Chou CC, Masto VB, Frydman J, Nixon RA. Elsasser S, et al. Among authors: morimoto ri. bioRxiv [Preprint]. 2023 Mar 24:2023.03.22.533675. doi: 10.1101/2023.03.22.533675. bioRxiv. 2023. PMID: 36993380 Free PMC article. Preprint.
Aging is associated with a systemic length-associated transcriptome imbalance.
Stoeger T, Grant RA, McQuattie-Pimentel AC, Anekalla KR, Liu SS, Tejedor-Navarro H, Singer BD, Abdala-Valencia H, Schwake M, Tetreault MP, Perlman H, Balch WE, Chandel NS, Ridge KM, Sznajder JI, Morimoto RI, Misharin AV, Budinger GRS, Nunes Amaral LA. Stoeger T, et al. Among authors: morimoto ri. Nat Aging. 2022 Dec;2(12):1191-1206. doi: 10.1038/s43587-022-00317-6. Epub 2022 Dec 9. Nat Aging. 2022. PMID: 37118543 Free PMC article.
Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia.
Rohani R, Scheetz MH, Donnelly HK, Donayre A, Kang M, Diaz E, Dedicatoria K, Hauser AR, Ozer EA, Nozick S, Qi C, Pawlowski AE, Neely MN, Misharin AV, Wunderink RG, Rhodes NJ; NU SCRIPT Study investigators. Rohani R, et al. J Antimicrob Chemother. 2022 Oct 28;77(11):2956-2959. doi: 10.1093/jac/dkac245. J Antimicrob Chemother. 2022. PMID: 35869779 Free PMC article.
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.
Capano LS, Sato C, Ficulle E, Yu A, Horie K, Kwon JS, Burbach KF, Barthélemy NR, Fox SG, Karch CM, Bateman RJ, Houlden H, Morimoto RI, Holtzman DM, Duff KE, Yoo AS. Capano LS, et al. Among authors: morimoto ri. Cell Stem Cell. 2022 Jun 2;29(6):918-932.e8. doi: 10.1016/j.stem.2022.04.018. Cell Stem Cell. 2022. PMID: 35659876 Free PMC article.
Variants in ATP6V0A1 cause progressive myoclonus epilepsy and developmental and epileptic encephalopathy.
Bott LC, Forouhan M, Lieto M, Sala AJ, Ellerington R, Johnson JO, Speciale AA, Criscuolo C, Filla A, Chitayat D, Alkhunaizi E, Shannon P, Nemeth AH; Italian Undiagnosed Diseases Network; Angelucci F, Lim WF, Striano P, Zara F, Helbig I, Muona M, Courage C, Lehesjoki AE, Berkovic SF; ATPase Consortium; Fischbeck KH, Brancati F, Morimoto RI, Wood MJA, Rinaldi C. Bott LC, et al. Among authors: morimoto ri. Brain Commun. 2021 Oct 18;3(4):fcab245. doi: 10.1093/braincomms/fcab245. eCollection 2021. Brain Commun. 2021. PMID: 34909687 Free PMC article.
Autophagy in healthy aging and disease.
Aman Y, Schmauck-Medina T, Hansen M, Morimoto RI, Simon AK, Bjedov I, Palikaras K, Simonsen A, Johansen T, Tavernarakis N, Rubinsztein DC, Partridge L, Kroemer G, Labbadia J, Fang EF. Aman Y, et al. Among authors: morimoto ri. Nat Aging. 2021 Aug;1(8):634-650. doi: 10.1038/s43587-021-00098-4. Epub 2021 Aug 12. Nat Aging. 2021. PMID: 34901876 Free PMC article. Review.
Protecting the future: balancing proteostasis for reproduction.
Sala AJ, Morimoto RI. Sala AJ, et al. Among authors: morimoto ri. Trends Cell Biol. 2022 Mar;32(3):202-215. doi: 10.1016/j.tcb.2021.09.009. Epub 2021 Oct 12. Trends Cell Biol. 2022. PMID: 34654604 Free PMC article. Review.
Correction: ERdj8 governs the size of autophagosomes during the formation process.
Yamamoto YH, Kasai A, Omori H, Takino T, Sugihara M, Umemoto T, Hamasaki M, Hatta T, Natsume T, Morimoto RI, Arai R, Waguri S, Sato M, Sato K, Bar-Nun S, Yoshimori T, Noda T, Nagata K. Yamamoto YH, et al. Among authors: morimoto ri. J Cell Biol. 2020 Sep 6;220(9):e20190312707282021c. doi: 10.1083/jcb.20190312707282021c. Epub 2021 Aug 6. J Cell Biol. 2020. PMID: 34357389 Free PMC article. No abstract available.
257 results