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Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice.
Bell RMB, Villalobos E, Nixon M, Miguelez-Crespo A, Murphy L, Fawkes A, Coutts A, Sharp MGF, Koerner MV, Allan E, Meijer OC, Houtman R, Odermatt A, Beck KR, Denham SG, Lee P, Homer NZM, Walker BR, Morgan RA. Bell RMB, et al. Among authors: morgan ra. Mol Metab. 2021 Jun;48:101225. doi: 10.1016/j.molmet.2021.101225. Epub 2021 Mar 27. Mol Metab. 2021. PMID: 33785425 Free PMC article.
Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.
Morgan RA, Beck KR, Nixon M, Homer NZM, Crawford AA, Melchers D, Houtman R, Meijer OC, Stomby A, Anderson AJ, Upreti R, Stimson RH, Olsson T, Michoel T, Cohain A, Ruusalepp A, Schadt EE, Björkegren JLM, Andrew R, Kenyon CJ, Hadoke PWF, Odermatt A, Keen JA, Walker BR. Morgan RA, et al. Sci Rep. 2017 Sep 6;7(1):10633. doi: 10.1038/s41598-017-10410-1. Sci Rep. 2017. PMID: 28878267 Free PMC article.
Comparison of mechanisms of angiostasis caused by the anti-inflammatory steroid 5α-tetrahydrocorticosterone versus conventional glucocorticoids.
Abernethie AJ, Gastaldello A, Maltese G, Morgan RA, McInnes KJ, Small GR, Walker BR, Livingstone DE, Hadoke PW, Andrew R. Abernethie AJ, et al. Among authors: morgan ra. Eur J Pharmacol. 2022 Aug 15;929:175111. doi: 10.1016/j.ejphar.2022.175111. Epub 2022 Jun 20. Eur J Pharmacol. 2022. PMID: 35738450 Free article.
Editorial: Steroid hormone receptors in cardiometabolic disease.
Goodwin J, Odermatt A, Morgan R, Nixon M. Goodwin J, et al. Front Endocrinol (Lausanne). 2023 Jul 19;14:1251897. doi: 10.3389/fendo.2023.1251897. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37538788 Free PMC article. No abstract available.
344 results