Morgan RA - Search Results

1

IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors.

Kerkar SP, Goldszmid RS, Muranski P, Chinnasamy D, Yu Z, Reger RN, Leonardi AJ, Morgan RA, Wang E, Marincola FM, Trinchieri G, Rosenberg SA, Restifo NP. Kerkar SP, et al. Among authors: morgan ra. J Clin Invest. 2011 Dec;121(12):4746-57. doi: 10.1172/JCI58814. Epub 2011 Nov 7. J Clin Invest. 2011. PMID: 22056381 Free PMC article.

2

Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hosts.

Kerkar SP, Muranski P, Kaiser A, Boni A, Sanchez-Perez L, Yu Z, Palmer DC, Reger RN, Borman ZA, Zhang L, Morgan RA, Gattinoni L, Rosenberg SA, Trinchieri G, Restifo NP. Kerkar SP, et al. Among authors: morgan ra. Cancer Res. 2010 Sep 1;70(17):6725-34. doi: 10.1158/0008-5472.CAN-10-0735. Epub 2010 Jul 20. Cancer Res. 2010. PMID: 20647327 Free PMC article.

3

Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice.

Chinnasamy D, Yu Z, Theoret MR, Zhao Y, Shrimali RK, Morgan RA, Feldman SA, Restifo NP, Rosenberg SA. Chinnasamy D, et al. Among authors: morgan ra. J Clin Invest. 2010 Nov;120(11):3953-68. doi: 10.1172/JCI43490. Epub 2010 Oct 11. J Clin Invest. 2010. PMID: 20978347 Free PMC article.

4

Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environment.

Zhang L, Kerkar SP, Yu Z, Zheng Z, Yang S, Restifo NP, Rosenberg SA, Morgan RA. Zhang L, et al. Among authors: morgan ra. Mol Ther. 2011 Apr;19(4):751-9. doi: 10.1038/mt.2010.313. Epub 2011 Feb 1. Mol Ther. 2011. PMID: 21285960 Free PMC article.

5

Local delivery of interleukin-12 using T cells targeting VEGF receptor-2 eradicates multiple vascularized tumors in mice.

Chinnasamy D, Yu Z, Kerkar SP, Zhang L, Morgan RA, Restifo NP, Rosenberg SA. Chinnasamy D, et al. Among authors: morgan ra. Clin Cancer Res. 2012 Mar 15;18(6):1672-83. doi: 10.1158/1078-0432.CCR-11-3050. Epub 2012 Jan 30. Clin Cancer Res. 2012. PMID: 22291136 Free PMC article.

6

Collapse of the tumor stroma is triggered by IL-12 induction of Fas.

Kerkar SP, Leonardi AJ, van Panhuys N, Zhang L, Yu Z, Crompton JG, Pan JH, Palmer DC, Morgan RA, Rosenberg SA, Restifo NP. Kerkar SP, et al. Among authors: morgan ra. Mol Ther. 2013 Jul;21(7):1369-77. doi: 10.1038/mt.2013.58. Epub 2013 Apr 9. Mol Ther. 2013. PMID: 23568260 Free PMC article.

7

Simultaneous targeting of tumor antigens and the tumor vasculature using T lymphocyte transfer synergize to induce regression of established tumors in mice.

Chinnasamy D, Tran E, Yu Z, Morgan RA, Restifo NP, Rosenberg SA. Chinnasamy D, et al. Among authors: morgan ra. Cancer Res. 2013 Jun 1;73(11):3371-80. doi: 10.1158/0008-5472.CAN-12-3913. Epub 2013 Apr 30. Cancer Res. 2013. PMID: 23633494 Free PMC article.

8

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia.

Tran E, Chinnasamy D, Yu Z, Morgan RA, Lee CC, Restifo NP, Rosenberg SA. Tran E, et al. Among authors: morgan ra. J Exp Med. 2013 Jun 3;210(6):1125-35. doi: 10.1084/jem.20130110. Epub 2013 May 27. J Exp Med. 2013. PMID: 23712432 Free PMC article.

9

Lack of specific gamma-retroviral vector long terminal repeat promoter silencing in patients receiving genetically engineered lymphocytes and activation upon lymphocyte restimulation.

Burns WR, Zheng Z, Rosenberg SA, Morgan RA. Burns WR, et al. Among authors: morgan ra. Blood. 2009 Oct 1;114(14):2888-99. doi: 10.1182/blood-2009-01-199216. Epub 2009 Jul 9. Blood. 2009. PMID: 19589923 Free PMC article.

10

Both CD4 and CD8 T cells mediate equally effective in vivo tumor treatment when engineered with a highly avid TCR targeting tyrosinase.

Frankel TL, Burns WR, Peng PD, Yu Z, Chinnasamy D, Wargo JA, Zheng Z, Restifo NP, Rosenberg SA, Morgan RA. Frankel TL, et al. Among authors: morgan ra. J Immunol. 2010 Jun 1;184(11):5988-98. doi: 10.4049/jimmunol.1000189. Epub 2010 Apr 28. J Immunol. 2010. PMID: 20427771 Free PMC article.

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