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Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis.
Evans R, Watkins LM, Hawkins K, Santiago G, Demetriou C, Naughton M, Dittmer M, Rees MI, Fitzgerald D, Morgan BP, Neal JW, Howell OW. Evans R, et al. Among authors: morgan bp. Front Cell Neurosci. 2023 Mar 22;17:1094106. doi: 10.3389/fncel.2023.1094106. eCollection 2023. Front Cell Neurosci. 2023. PMID: 37032838 Free PMC article.
Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility.
Romero A, Ashcraft L, Chandra A, DiMassa V, Cremin P, Collibee SE, Chuang C, Hartman J, Hwee DT, St Jean D, Malinowski J, DeBenedetto M, Moebius D, Payette J, Vargas R, Yeoman J, Motani A, Reagan J, Malik FI, Morgan BP. Romero A, et al. Among authors: morgan bp. J Med Chem. 2024 May 10. doi: 10.1021/acs.jmedchem.3c02413. Online ahead of print. J Med Chem. 2024. PMID: 38729623
The complement system in neurodegenerative diseases.
Nimmo J, Byrne RAJ, Daskoulidou N, Watkins LM, Carpanini SM, Zelek WM, Morgan BP. Nimmo J, et al. Among authors: morgan bp. Clin Sci (Lond). 2024 Mar 20;138(6):387-412. doi: 10.1042/CS20230513. Clin Sci (Lond). 2024. PMID: 38505993 Free PMC article.
Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats.
Collibee SE, Romero A, Muci AR, Hwee DT, Chuang C, Hartman JJ, Motani AS, Ashcraft L, DeRosier A, Grillo M, Lu Q, Malik FI, Morgan BP. Collibee SE, et al. Among authors: morgan bp. J Med Chem. 2024 Mar 7. doi: 10.1021/acs.jmedchem.3c02412. Online ahead of print. J Med Chem. 2024. PMID: 38451215
Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation.
Bowen EE, Hurcombe JA, Barrington F, Keir LS, Farmer LK, Wherlock MD, Ortiz-Sandoval CG, Bruno V, Bohorquez-Hernandez A, Diatlov D, Rostam-Shirazi N, Wells S, Stewart M, Teboul L, Lay AC, Butler MJ, Pope RJP, Larkai EMS, Morgan BP, Moppett J, Satchell SC, Welsh GI, Walker PD, Licht C, Saleem MA, Coward RJM. Bowen EE, et al. Among authors: morgan bp. Med. 2023 Nov 10;4(11):761-777.e8. doi: 10.1016/j.medj.2023.09.002. Epub 2023 Oct 19. Med. 2023. PMID: 37863058 Free article.
528 results