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The mutation R107Q alters mtSSB ssDNA compaction ability and binding dynamics.
Martucci M, Moretton A, Tarrés-Solé A, Ropars V, Lambert L, Vernet P, Solà M, Falkenberg M, Farge G, van den Wildenberg S. Martucci M, et al. Among authors: moretton a. Nucleic Acids Res. 2024 May 14:gkae354. doi: 10.1093/nar/gkae354. Online ahead of print. Nucleic Acids Res. 2024. PMID: 38742632
Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy.
Slyskova J, Muniesa-Vargas A, da Silva IT, Drummond R, Park J, Häckes D, Poetsch I, Ribeiro-Silva C, Moretton A, Heffeter P, Schärer OD, Vermeulen W, Lans H, Loizou JI. Slyskova J, et al. Among authors: moretton a. NAR Cancer. 2023 Dec 5;5(4):zcad057. doi: 10.1093/narcan/zcad057. eCollection 2023 Dec. NAR Cancer. 2023. PMID: 38058548 Free PMC article.
A metabolic map of the DNA damage response identifies PRDX1 in the control of nuclear ROS scavenging and aspartate availability.
Moretton A, Kourtis S, Gañez Zapater A, Calabrò C, Espinar Calvo ML, Fontaine F, Darai E, Abad Cortel E, Block S, Pascual-Reguant L, Pardo-Lorente N, Ghose R, Vander Heiden MG, Janic A, Müller AC, Loizou JI, Sdelci S. Moretton A, et al. Mol Syst Biol. 2023 Jul 11;19(7):e11267. doi: 10.15252/msb.202211267. Epub 2023 Jun 1. Mol Syst Biol. 2023. PMID: 37259925 Free PMC article.
Selective mitochondrial DNA degradation following double-strand breaks.
Moretton A, Morel F, Macao B, Lachaume P, Ishak L, Lefebvre M, Garreau-Balandier I, Vernet P, Falkenberg M, Farge G. Moretton A, et al. PLoS One. 2017 Apr 28;12(4):e0176795. doi: 10.1371/journal.pone.0176795. eCollection 2017. PLoS One. 2017. PMID: 28453550 Free PMC article.