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Modifications at C(5) of 2-(2-Pyrrolidinyl)-Substituted 1,4-Benzodioxane Elicit Potent α4β2 Nicotinic Acetylcholine Receptor Partial Agonism with High Selectivity over the α3β4 Subtype.
Bavo F, Pallavicini M, Gotti C, Appiani R, Moretti M, Colombo SF, Pucci S, Viani P, Budriesi R, Renzi M, Fucile S, Bolchi C. Bavo F, et al. Among authors: moretti m. J Med Chem. 2020 Dec 24;63(24):15668-15692. doi: 10.1021/acs.jmedchem.0c01150. Epub 2020 Dec 16. J Med Chem. 2020. PMID: 33325696 Free article.
5-(2-Pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes: synthesis of all the stereoisomers and alpha4beta2 nicotinic affinity.
Pallavicini M, Bolchi C, Binda M, Cilia A, Clementi F, Ferrara R, Fumagalli L, Gotti C, Moretti M, Pedretti A, Vistoli G, Valoti E. Pallavicini M, et al. Among authors: moretti m. Bioorg Med Chem Lett. 2009 Feb 1;19(3):854-9. doi: 10.1016/j.bmcl.2008.12.002. Epub 2008 Dec 6. Bioorg Med Chem Lett. 2009. PMID: 19097783
Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an α7-nAChR, α9-nAChR Antagonist and of a Pro-Oxidant Mitocan.
Bavo F, Pucci S, Fasoli F, Lammi C, Moretti M, Mucchietto V, Lattuada D, Viani P, De Palma C, Budriesi R, Corradini I, Dowell C, McIntosh JM, Clementi F, Bolchi C, Gotti C, Pallavicini M. Bavo F, et al. Among authors: moretti m. J Med Chem. 2018 Dec 13;61(23):10531-10544. doi: 10.1021/acs.jmedchem.8b01052. Epub 2018 Nov 26. J Med Chem. 2018. PMID: 30403486
Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors.
Murineddu G, Gotti C, Asproni B, Corona P, Martinello K, Plutino S, Fucile S, Temml V, Moretti M, Viani P, Schuster D, Piras S, Deligia F, Pinna GA. Murineddu G, et al. Among authors: moretti m. Eur J Med Chem. 2019 Oct 15;180:51-61. doi: 10.1016/j.ejmech.2019.06.079. Epub 2019 Jul 5. Eur J Med Chem. 2019. PMID: 31299587 Free article.
Behavioural and pharmacological profiles of zebrafish administrated pyrrolidinyl benzodioxanes and prolinol aryl ethers with high affinity for heteromeric nicotinic acetylcholine receptors.
Braida D, Ponzoni L, Moretti M, Viani P, Pallavicini M, Bolchi C, Appiani R, Bavo F, Gotti C, Sala M. Braida D, et al. Among authors: moretti m. Psychopharmacology (Berl). 2020 Aug;237(8):2317-2326. doi: 10.1007/s00213-020-05536-6. Epub 2020 May 7. Psychopharmacology (Berl). 2020. PMID: 32382782 Free article.
From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human α9α10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue.
Bavo F, Pallavicini M, Pucci S, Appiani R, Giraudo A, Eaton B, Lucero L, Gotti C, Moretti M, Whiteaker P, Bolchi C. Bavo F, et al. Among authors: moretti m. J Med Chem. 2022 Jul 28;65(14):10079-10097. doi: 10.1021/acs.jmedchem.2c00746. Epub 2022 Jul 14. J Med Chem. 2022. PMID: 35834819 Free PMC article.
1,394 results