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Correction: 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases.
Rossi MA, Martinez V, Hinchliffe P, Mojica MF, Castillo V, Moreno DM, Smith R, Spellberg B, Drusano GL, Banchio C, Bonomo RA, Spencer J, Vila AJ, Mahler G. Rossi MA, et al. Among authors: moreno dm. Chem Sci. 2023 Aug 15;14(34):9226. doi: 10.1039/d3sc90150e. eCollection 2023 Aug 30. Chem Sci. 2023. PMID: 37655038 Free PMC article.
Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.
Villamil V, Rossi MA, Mojica MF, Hinchliffe P, Martínez V, Castillo V, Saiz C, Banchio C, Macías MA, Spencer J, Bonomo RA, Vila A, Moreno DM, Mahler G. Villamil V, et al. Among authors: moreno dm. J Med Chem. 2024 Mar 14;67(5):3795-3812. doi: 10.1021/acs.jmedchem.3c02209. Epub 2024 Feb 19. J Med Chem. 2024. PMID: 38373290
A Transmembrane Histidine Kinase Functions as a pH Sensor.
Bortolotti A, Vazquez DB, Almada JC, Inda ME, Drusin SI, Villalba JM, Moreno DM, Ruysschaert JM, Cybulski LE. Bortolotti A, et al. Among authors: moreno dm. Biomolecules. 2020 Aug 14;10(8):1183. doi: 10.3390/biom10081183. Biomolecules. 2020. PMID: 32823946 Free PMC article.
2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-β-Lactamase Classes by Maintaining a Conserved Binding Mode.
Hinchliffe P, Moreno DM, Rossi MA, Mojica MF, Martinez V, Villamil V, Spellberg B, Drusano GL, Banchio C, Mahler G, Bonomo RA, Vila AJ, Spencer J. Hinchliffe P, et al. Among authors: moreno dm. ACS Infect Dis. 2021 Sep 10;7(9):2697-2706. doi: 10.1021/acsinfecdis.1c00194. Epub 2021 Aug 6. ACS Infect Dis. 2021. PMID: 34355567 Free PMC article.
Shaping Substrate Selectivity in a Broad-Spectrum Metallo-β-Lactamase.
González LJ, Stival C, Puzzolo JL, Moreno DM, Vila AJ. González LJ, et al. Among authors: moreno dm. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e02079-17. doi: 10.1128/AAC.02079-17. Print 2018 Apr. Antimicrob Agents Chemother. 2018. PMID: 29358299 Free PMC article.
46 results