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The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase.
Epigenetics Chromatin. 2023 May 13;16(1):18. doi: 10.1186/s13072-023-00494-7.
Epigenetics Chromatin. 2023.
PMID: 37179361
Free PMC article.
The VRK1 chromatin kinase regulates the acetyltransferase activity of Tip60/KAT5 by sequential phosphorylations in response to DNA damage.
García-González R, Monte-Serrano E, Morejón-García P, Navarro-Carrasco E, Lazo PA.
García-González R, et al. Among authors: morejon garcia p.
Biochim Biophys Acta Gene Regul Mech. 2022 Nov;1865(8):194887. doi: 10.1016/j.bbagrm.2022.194887. Epub 2022 Oct 21.
Biochim Biophys Acta Gene Regul Mech. 2022.
PMID: 36280132
Free article.
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VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage.
García-González R, Morejón-García P, Campillo-Marcos I, Salzano M, Lazo PA.
García-González R, et al. Among authors: morejon garcia p.
Cancers (Basel). 2020 Oct 15;12(10):2986. doi: 10.3390/cancers12102986.
Cancers (Basel). 2020.
PMID: 33076429
Free PMC article.
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VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy.
Marcos AT, Martín-Doncel E, Morejón-García P, Marcos-Alcalde I, Gómez-Puertas P, Segura-Puimedon M, Armengol L, Navarro-Pando JM, Lazo PA.
Marcos AT, et al. Among authors: morejon garcia p.
Ann Clin Transl Neurol. 2020 May;7(5):808-818. doi: 10.1002/acn3.51050. Epub 2020 May 4.
Ann Clin Transl Neurol. 2020.
PMID: 32365420
Free PMC article.
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Dysfunctional Homozygous VRK1-D263G Variant Impairs the Assembly of Cajal Bodies and DNA Damage Response in Hereditary Spastic Paraplegia.
Morejon-Garcia P, Keren B, Marcos-Alcalde I, Gomez-Puertas P, Mochel F, Lazo PA.
Morejon-Garcia P, et al.
Neurol Genet. 2021 Sep 2;7(5):e624. doi: 10.1212/NXG.0000000000000624. eCollection 2021 Oct.
Neurol Genet. 2021.
PMID: 34504951
Free PMC article.
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Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy.
Campos-Díaz A, Morejón-García P, Monte-Serrano E, Ros-Pardo D, Marcos-Alcalde I, Gómez-Puertas P, Lazo PA.
Campos-Díaz A, et al. Among authors: morejon garcia p.
J Mol Med (Berl). 2024 Mar 30. doi: 10.1007/s00109-024-02442-8. Online ahead of print.
J Mol Med (Berl). 2024.
PMID: 38554151
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VRK1 variants at the cross road of Cajal body neuropathogenic mechanisms in distal neuropathies and motor neuron diseases.
Lazo PA, Morejón-García P.
Lazo PA, et al. Among authors: morejon garcia p.
Neurobiol Dis. 2023 Jul;183:106172. doi: 10.1016/j.nbd.2023.106172. Epub 2023 May 29.
Neurobiol Dis. 2023.
PMID: 37257665
Free article.
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