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Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate.
Simpson JB, Sekela JJ, Graboski AL, Borlandelli VB, Bivins MM, Barker NK, Sorgen AA, Mordant AL, Johnson RL, Bhatt AP, Fodor AA, Herring LE, Overkleeft H, Lee JR, Redinbo MR. Simpson JB, et al. Among authors: mordant al. Gut Microbes. 2022 Jan-Dec;14(1):2107289. doi: 10.1080/19490976.2022.2107289. Gut Microbes. 2022. PMID: 35953888 Free PMC article.
Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals.
Fritch EJ, Mordant AL, Gilbert TSK, Wells CI, Yang X, Barker NK, Madden EA, Dinnon KH 3rd, Hou YJ, Tse LV, Castillo IN, Sims AC, Moorman NJ, Lakshmanane P, Willson TM, Herring LE, Graves LM, Baric RS. Fritch EJ, et al. Among authors: mordant al. J Proteome Res. 2023 Oct 6;22(10):3159-3177. doi: 10.1021/acs.jproteome.3c00182. Epub 2023 Aug 27. J Proteome Res. 2023. PMID: 37634194
Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
Merten EM, Sears JD, Leisner TM, Hardy PB, Ghoshal A, Hossain MA, Asressu KH, Brown PJ, Stashko MA, Herring LE, Mordant AL, Webb TS, Mills CA, Barker NK, Arnold JJ, Cameron CE, Streblow DN, Moorman NJ, Heise M, Willson TM, Popov KI, Pearce KH. Merten EM, et al. Among authors: mordant al. bioRxiv [Preprint]. 2024 Mar 22:2024.03.22.586341. doi: 10.1101/2024.03.22.586341. bioRxiv. 2024. PMID: 38562906 Free PMC article. Preprint.
Developing forebrain synapses are uniquely vulnerable to sleep loss.
Gay SM, Chartampila E, Lord JS, Grizzard S, Maisashvili T, Ye M, Barker NK, Mordant AL, Mills CA, Herring LE, Diering GH. Gay SM, et al. Among authors: mordant al. bioRxiv [Preprint]. 2024 Apr 12:2023.11.06.565853. doi: 10.1101/2023.11.06.565853. bioRxiv. 2024. PMID: 37986967 Free PMC article. Preprint.