Moran P - Search Results

1

The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody.

Ciferri C, Lipari MT, Liang WC, Estevez A, Hang J, Stawicki S, Wu Y, Moran P, Elliott M, Eigenbrot C, Katschke KJ, van Lookeren Campagne M, Kirchhofer D. Ciferri C, et al. Among authors: moran p. Biochem J. 2015 Dec 1;472(2):169-81. doi: 10.1042/BJ20150601. Epub 2015 Sep 18. Biochem J. 2015. PMID: 26385991

2

Structural and functional analysis of HtrA1 and its subdomains.

Eigenbrot C, Ultsch M, Lipari MT, Moran P, Lin SJ, Ganesan R, Quan C, Tom J, Sandoval W, van Lookeren Campagne M, Kirchhofer D. Eigenbrot C, et al. Among authors: moran p. Structure. 2012 Jun 6;20(6):1040-50. doi: 10.1016/j.str.2012.03.021. Epub 2012 May 10. Structure. 2012. PMID: 22578544 Free article.

3

Structural insight into how an anti-idiotypic antibody against D3H44 (anti-tissue factor antibody) restores normal coagulation.

Eigenbrot C, Meng YG, Krishnamurthy R, Lipari MT, Presta L, Devaux B, Wong T, Moran P, Bullens S, Kirchhofer D. Eigenbrot C, et al. Among authors: moran p. J Mol Biol. 2003 Aug 8;331(2):433-46. doi: 10.1016/s0022-2836(03)00735-6. J Mol Biol. 2003. PMID: 12888350

4

Kelley RF, Yang J, Eigenbrot C, Moran P, Peek M, Lipari MT, Kirchhofer D. Kelley RF, et al. Among authors: moran p. Biochemistry. 2004 Feb 10;43(5):1223-9. doi: 10.1021/bi035738i. Biochemistry. 2004. PMID: 14756558

5

Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling.

Kirchhofer D, Yao X, Peek M, Eigenbrot C, Lipari MT, Billeci KL, Maun HR, Moran P, Santell L, Wiesmann C, Lazarus RA. Kirchhofer D, et al. Among authors: moran p. J Biol Chem. 2004 Sep 17;279(38):39915-24. doi: 10.1074/jbc.M404795200. Epub 2004 Jun 24. J Biol Chem. 2004. PMID: 15218027 Free article.

6

Pro-urokinase-type plasminogen activator is a substrate for hepsin.

Moran P, Li W, Fan B, Vij R, Eigenbrot C, Kirchhofer D. Moran P, et al. J Biol Chem. 2006 Oct 13;281(41):30439-46. doi: 10.1074/jbc.M605440200. Epub 2006 Aug 14. J Biol Chem. 2006. PMID: 16908524 Free article.

7

Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist.

Kirchhofer D, Lipari MT, Santell L, Billeci KL, Maun HR, Sandoval WN, Moran P, Ridgway J, Eigenbrot C, Lazarus RA. Kirchhofer D, et al. Among authors: moran p. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5306-11. doi: 10.1073/pnas.0700184104. Epub 2007 Mar 19. Proc Natl Acad Sci U S A. 2007. PMID: 17372204 Free PMC article.

8

An allosteric anti-hepsin antibody derived from a constrained phage display library.

Ganesan R, Zhang Y, Landgraf KE, Lin SJ, Moran P, Kirchhofer D. Ganesan R, et al. Among authors: moran p. Protein Eng Des Sel. 2012 Mar;25(3):127-33. doi: 10.1093/protein/gzr067. Epub 2012 Jan 18. Protein Eng Des Sel. 2012. PMID: 22258274

9

Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2.

Kirchhofer D, Peek M, Lipari MT, Billeci K, Fan B, Moran P. Kirchhofer D, et al. Among authors: moran p. FEBS Lett. 2005 Mar 28;579(9):1945-50. doi: 10.1016/j.febslet.2005.01.085. FEBS Lett. 2005. PMID: 15792801 Free article.

10

Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels.

Lipari MT, Li W, Moran P, Kong-Beltran M, Sai T, Lai J, Lin SJ, Kolumam G, Zavala-Solorio J, Izrael-Tomasevic A, Arnott D, Wang J, Peterson AS, Kirchhofer D. Lipari MT, et al. Among authors: moran p. J Biol Chem. 2012 Dec 21;287(52):43482-91. doi: 10.1074/jbc.M112.380618. Epub 2012 Nov 7. J Biol Chem. 2012. PMID: 23135270 Free PMC article.

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