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Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes.
Rudman N, Kaur S, Simunović V, Kifer D, Šoić D, Keser T, Štambuk T, Klarić L, Pociot F, Morahan G, Gornik O. Rudman N, et al. Among authors: morahan g. Diabetologia. 2023 Jun;66(6):1071-1083. doi: 10.1007/s00125-023-05881-z. Epub 2023 Mar 13. Diabetologia. 2023. PMID: 36907892 Free PMC article.
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3.
Concannon P, Onengut-Gumuscu S, Todd JA, Smyth DJ, Pociot F, Bergholdt R, Akolkar B, Erlich HA, Hilner JE, Julier C, Morahan G, Nerup J, Nierras CR, Chen WM, Rich SS; Type 1 Diabetes Genetics Consortium. Concannon P, et al. Among authors: morahan g. Diabetes. 2008 Oct;57(10):2858-61. doi: 10.2337/db08-0753. Epub 2008 Jul 22. Diabetes. 2008. PMID: 18647951 Free PMC article.
No association of the IRS1 and PAX4 genes with type I diabetes.
Bergholdt R, Brorsson C, Boehm B, Morahan G, Pociot F; Type I Diabetes Genetics Consortium. Bergholdt R, et al. Among authors: morahan g. Genes Immun. 2009 Dec;10 Suppl 1(Suppl 1):S49-53. doi: 10.1038/gene.2009.91. Genes Immun. 2009. PMID: 19956100 Free PMC article.
Genetics of type 1 diabetes: what's next?
Pociot F, Akolkar B, Concannon P, Erlich HA, Julier C, Morahan G, Nierras CR, Todd JA, Rich SS, Nerup J. Pociot F, et al. Among authors: morahan g. Diabetes. 2010 Jul;59(7):1561-71. doi: 10.2337/db10-0076. Diabetes. 2010. PMID: 20587799 Free PMC article. Review. No abstract available.
Confirmation of novel type 1 diabetes risk loci in families.
Cooper JD, Howson JM, Smyth D, Walker NM, Stevens H, Yang JH, She JX, Eisenbarth GS, Rewers M, Todd JA, Akolkar B, Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Rich SS; Type 1 Diabetes Genetics Consortium. Cooper JD, et al. Among authors: morahan g. Diabetologia. 2012 Apr;55(4):996-1000. doi: 10.1007/s00125-012-2450-3. Epub 2012 Jan 26. Diabetologia. 2012. PMID: 22278338 Free PMC article.
CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients.
Fløyel T, Brorsson C, Nielsen LB, Miani M, Bang-Berthelsen CH, Friedrichsen M, Overgaard AJ, Berchtold LA, Wiberg A, Poulsen P, Hansen L, Rosinger S, Boehm BO, Ram R, Nguyen Q, Mehta M, Morahan G, Concannon P, Bergholdt R, Nielsen JH, Reinheckel T, von Herrath M, Vaag A, Eizirik DL, Mortensen HB, Størling J, Pociot F. Fløyel T, et al. Among authors: morahan g. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10305-10. doi: 10.1073/pnas.1402571111. Epub 2014 Jun 30. Proc Natl Acad Sci U S A. 2014. PMID: 24982147 Free PMC article. Clinical Trial.
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