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Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation.
J Biol Chem. 2020 Mar 6;295(10):3330-3346. doi: 10.1074/jbc.RA120.012533. Epub 2020 Jan 23.
J Biol Chem. 2020.
PMID: 31974165
Free PMC article.
Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes.
Al-Oanzi ZH, Fountana S, Moonira T, Tudhope SJ, Petrie JL, Alshawi A, Patman G, Arden C, Reeves HL, Agius L.
Al-Oanzi ZH, et al. Among authors: moonira t.
Diabetes Obes Metab. 2017 Aug;19(8):1078-1087. doi: 10.1111/dom.12910. Epub 2017 Apr 10.
Diabetes Obes Metab. 2017.
PMID: 28206714
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The GCKR-P446L gene variant predisposes to raised blood cholesterol and lower blood glucose in the P446L mouse-a model for GCKR rs1260326.
Ford BE, Chachra SS, Rodgers K, Moonira T, Al-Oanzi ZH, Anstee QM, Reeves HL, Schattenberg JM, Fairclough RJ, Smith DM, Tiniakos D, Agius L.
Ford BE, et al. Among authors: moonira t.
Mol Metab. 2023 Jun;72:101722. doi: 10.1016/j.molmet.2023.101722. Epub 2023 Apr 7.
Mol Metab. 2023.
PMID: 37031802
Free PMC article.
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