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Screening out irrelevant cell-based models of disease.
Horvath P, Aulner N, Bickle M, Davies AM, Nery ED, Ebner D, Montoya MC, Östling P, Pietiäinen V, Price LS, Shorte SL, Turcatti G, von Schantz C, Carragher NO. Horvath P, et al. Among authors: montoya mc. Nat Rev Drug Discov. 2016 Nov;15(11):751-769. doi: 10.1038/nrd.2016.175. Epub 2016 Sep 12. Nat Rev Drug Discov. 2016. PMID: 27616293 Review.
Cell-based fuzzy metrics enhance high-content screening (HCS) assay robustness.
Azegrouz H, Karemore G, Torres A, Alaíz CM, Gonzalez AM, Nevado P, Salmerón A, Pellinen T, del Pozo MA, Dorronsoro JR, Montoya MC. Azegrouz H, et al. Among authors: montoya mc. J Biomol Screen. 2013 Dec;18(10):1270-83. doi: 10.1177/1087057113501554. Epub 2013 Sep 17. J Biomol Screen. 2013. PMID: 24045580
Tox_(R)CNN: Deep learning-based nuclei profiling tool for drug toxicity screening.
Jimenez-Carretero D, Abrishami V, Fernández-de-Manuel L, Palacios I, Quílez-Álvarez A, Díez-Sánchez A, Del Pozo MA, Montoya MC. Jimenez-Carretero D, et al. Among authors: montoya mc. PLoS Comput Biol. 2018 Nov 30;14(11):e1006238. doi: 10.1371/journal.pcbi.1006238. eCollection 2018 Nov. PLoS Comput Biol. 2018. PMID: 30500821 Free PMC article.
ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer.
Pellinen T, Blom S, Sánchez S, Välimäki K, Mpindi JP, Azegrouz H, Strippoli R, Nieto R, Vitón M, Palacios I, Turkki R, Wang Y, Sánchez-Alvarez M, Nordling S, Bützow A, Mirtti T, Rannikko A, Montoya MC, Kallioniemi O, Del Pozo MA. Pellinen T, et al. Among authors: montoya mc. Sci Rep. 2018 Feb 5;8(1):2338. doi: 10.1038/s41598-018-20161-2. Sci Rep. 2018. PMID: 29402961 Free PMC article.
69 results