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A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo.
Nguyen HA, Su Y, Zhang JY, Antanasijevic A, Caffrey M, Schalk AM, Liu L, Rondelli D, Oh A, Mahmud DL, Bosland MC, Kajdacsy-Balla A, Peirs S, Lammens T, Mondelaers V, De Moerloose B, Goossens S, Schlicht MJ, Kabirov KK, Lyubimov AV, Merrill BJ, Saunthararajah Y, Van Vlierberghe P, Lavie A. Nguyen HA, et al. Among authors: mondelaers v. Cancer Res. 2018 Mar 15;78(6):1549-1560. doi: 10.1158/0008-5472.CAN-17-2106. Epub 2018 Jan 17. Cancer Res. 2018. PMID: 29343523 Free PMC article.
Prospective, real-time monitoring of pegylated Escherichia coli and Erwinia asparaginase therapy in childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma in Belgium.
Mondelaers V, Ferster A, Uyttebroeck A, Brichard B, van der Werff Ten Bosch J, Norga K, Francotte N, Piette C, Vandemeulebroecke K, Verbeke C, Schmidt S, Benoit Y, Lammens T, De Moerloose B. Mondelaers V, et al. Br J Haematol. 2020 Jul;190(1):105-114. doi: 10.1111/bjh.16495. Epub 2020 Feb 14. Br J Haematol. 2020. PMID: 32057100 Free article.
In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia.
Van Trimpont M, Schalk AM, De Visser Y, Nguyen HA, Reunes L, Vandemeulebroecke K, Peeters E, Su Y, Lee H, Lorenzi PL, Chan WK, Mondelaers V, De Moerloose B, Lammens T, Goossens S, Van Vlierberghe P, Lavie A. Van Trimpont M, et al. Among authors: mondelaers v. Haematologica. 2023 Feb 1;108(2):409-419. doi: 10.3324/haematol.2022.281390. Haematologica. 2023. PMID: 35979719 Free PMC article.
Prolonged versus standard native E. coli asparaginase therapy in childhood acute lymphoblastic leukemia and non-Hodgkin lymphoma: final results of the EORTC-CLG randomized phase III trial 58951.
Mondelaers V, Suciu S, De Moerloose B, Ferster A, Mazingue F, Plat G, Yakouben K, Uyttebroeck A, Lutz P, Costa V, Sirvent N, Plouvier E, Munzer M, Poirée M, Minckes O, Millot F, Plantaz D, Maes P, Hoyoux C, Cavé H, Rohrlich P, Bertrand Y, Benoit Y; Children–s Leukemia Group (CLG) of the European Organization for Research and Treatment of Cancer (EORTC). Mondelaers V, et al. Haematologica. 2017 Oct;102(10):1727-1738. doi: 10.3324/haematol.2017.165845. Epub 2017 Jul 27. Haematologica. 2017. PMID: 28751566 Free PMC article. Clinical Trial.
Hypersensitivity to Pegylated E.coli asparaginase as first-line treatment in contemporary paediatric acute lymphoblastic leukaemia protocols: a meta-analysis of the Ponte di Legno Toxicity working group.
Brigitha LJ, Fiocco M, Pieters R, Albertsen BK, Escherich G, Lopez-Lopez E, Mondelaers V, Vora A, Vrooman L, Schmiegelow K, van der Sluis IM; Ponte di Legno Toxicity Working Group. Brigitha LJ, et al. Among authors: mondelaers v. Eur J Cancer. 2022 Feb;162:65-75. doi: 10.1016/j.ejca.2021.11.016. Epub 2021 Dec 23. Eur J Cancer. 2022. PMID: 34954438 Free article.
Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation.
van der Sluis IM, Vrooman LM, Pieters R, Baruchel A, Escherich G, Goulden N, Mondelaers V, Sanchez de Toledo J, Rizzari C, Silverman LB, Whitlock JA. van der Sluis IM, et al. Among authors: mondelaers v. Haematologica. 2016 Mar;101(3):279-85. doi: 10.3324/haematol.2015.137380. Haematologica. 2016. PMID: 26928249 Free PMC article.
23 results