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Lipoic-based TRPA1/TRPV1 antagonist to treat orofacial pain.
Gualdani R, Ceruti S, Magni G, Merli D, Di Cesare Mannelli L, Francesconi O, Richichi B, la Marca G, Ghelardini C, Moncelli MR, Nativi C. Gualdani R, et al. Among authors: moncelli mr. ACS Chem Neurosci. 2015 Mar 18;6(3):380-5. doi: 10.1021/cn500248u. Epub 2015 Jan 6. ACS Chem Neurosci. 2015. PMID: 25546551
A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain.
Nativi C, Gualdani R, Dragoni E, Di Cesare Mannelli L, Sostegni S, Norcini M, Gabrielli G, la Marca G, Richichi B, Francesconi O, Moncelli MR, Ghelardini C, Roelens S. Nativi C, et al. Among authors: moncelli mr. Sci Rep. 2013;3:2005. doi: 10.1038/srep02005. Sci Rep. 2013. PMID: 23774285 Free PMC article.
Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel.
Materazzi S, Benemei S, Fusi C, Gualdani R, De Siena G, Vastani N, Andersson DA, Trevisan G, Moncelli MR, Wei X, Dussor G, Pollastro F, Patacchini R, Appendino G, Geppetti P, Nassini R. Materazzi S, et al. Among authors: moncelli mr. Pain. 2013 Dec;154(12):2750-2758. doi: 10.1016/j.pain.2013.08.002. Epub 2013 Aug 8. Pain. 2013. PMID: 23933184 Free PMC article.
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.
Gemma S, Camodeca C, Brindisi M, Brogi S, Kukreja G, Kunjir S, Gabellieri E, Lucantoni L, Habluetzel A, Taramelli D, Basilico N, Gualdani R, Tadini-Buoninsegni F, Bartolommei G, Moncelli MR, Martin RE, Summers RL, Lamponi S, Savini L, Fiorini I, Valoti M, Novellino E, Campiani G, Butini S. Gemma S, et al. Among authors: moncelli mr. J Med Chem. 2012 Dec 13;55(23):10387-404. doi: 10.1021/jm300831b. Epub 2012 Nov 21. J Med Chem. 2012. PMID: 23145816
Phospholamban generates cation selective ion channels.
Smeazzetto S, Schröder I, Thiel G, Moncelli MR. Smeazzetto S, et al. Among authors: moncelli mr. Phys Chem Chem Phys. 2011 Jul 28;13(28):12935-9. doi: 10.1039/c1cp20460b. Epub 2011 Jun 20. Phys Chem Chem Phys. 2011. PMID: 21687864
The Ca2+-ATPase (SERCA1) is inhibited by 4-aminoquinoline derivatives through interference with catalytic activation by Ca2+, whereas the ATPase E2 state remains functional.
Bartolommei G, Tadini-Buoninsegni F, Moncelli MR, Gemma S, Camodeca C, Butini S, Campiani G, Lewis D, Inesi G. Bartolommei G, et al. Among authors: moncelli mr. J Biol Chem. 2011 Nov 4;286(44):38383-38389. doi: 10.1074/jbc.M111.287276. Epub 2011 Sep 13. J Biol Chem. 2011. PMID: 21914795 Free PMC article.
48 results