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Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance.
Lan T, Ganapathy US, Sharma S, Ahn YM, Zimmerman M, Molodtsov V, Hegde P, Gengenbacher M, Ebright RH, Dartois V, Freundlich JS, Dick T, Aldrich CC. Lan T, et al. Among authors: molodtsov v. Angew Chem Int Ed Engl. 2022 Nov 7;61(45):e202211498. doi: 10.1002/anie.202211498. Epub 2022 Oct 12. Angew Chem Int Ed Engl. 2022. PMID: 36222275 Free PMC article.
Structural basis of transcription-translation coupling.
Wang C, Molodtsov V, Firlar E, Kaelber JT, Blaha G, Su M, Ebright RH. Wang C, et al. Among authors: molodtsov v. Science. 2020 Sep 11;369(6509):1359-1365. doi: 10.1126/science.abb5317. Epub 2020 Aug 20. Science. 2020. PMID: 32820061 Free PMC article.
Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
Ma Z, He S, Yuan Y, Zhuang Z, Liu Y, Wang H, Chen J, Xu X, Ding C, Molodtsov V, Lin W, Robertson GT, Weiss WJ, Pulse M, Nguyen P, Duncan L, Doyle T, Ebright RH, Lynch AS. Ma Z, et al. Among authors: molodtsov v. J Med Chem. 2022 Mar 24;65(6):4481-4495. doi: 10.1021/acs.jmedchem.1c02045. Epub 2022 Feb 17. J Med Chem. 2022. PMID: 35175750 Free PMC article.
Structural and mechanistic basis of σ-dependent transcriptional pausing.
Pukhrambam C, Molodtsov V, Kooshkbaghi M, Tareen A, Vu H, Skalenko KS, Su M, Yin Z, Winkelman JT, Kinney JB, Ebright RH, Nickels BE. Pukhrambam C, et al. Among authors: molodtsov v. Proc Natl Acad Sci U S A. 2022 Jun 7;119(23):e2201301119. doi: 10.1073/pnas.2201301119. Epub 2022 Jun 2. Proc Natl Acad Sci U S A. 2022. PMID: 35653571 Free PMC article.
Structural basis of Rho-dependent transcription termination.
Molodtsov V, Wang C, Firlar E, Kaelber JT, Ebright RH. Molodtsov V, et al. Nature. 2023 Feb;614(7947):367-374. doi: 10.1038/s41586-022-05658-1. Epub 2023 Jan 25. Nature. 2023. PMID: 36697824 Free PMC article.
X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein.
Molodtsov V, Fleming PR, Eyermann CJ, Ferguson AD, Foulk MA, McKinney DC, Masse CE, Buurman ET, Murakami KS. Molodtsov V, et al. J Med Chem. 2015 Apr 9;58(7):3156-71. doi: 10.1021/acs.jmedchem.5b00050. Epub 2015 Mar 23. J Med Chem. 2015. PMID: 25798859 Free PMC article.
43 results