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Tau protein liquid-liquid phase separation can initiate tau aggregation.
EMBO J. 2018 Apr 3;37(7):e98049. doi: 10.15252/embj.201798049. Epub 2018 Feb 22.
EMBO J. 2018.
PMID: 29472250
Free PMC article.
Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization.
Molliex A, Temirov J, Lee J, Coughlin M, Kanagaraj AP, Kim HJ, Mittag T, Taylor JP.
Molliex A, et al.
Cell. 2015 Sep 24;163(1):123-33. doi: 10.1016/j.cell.2015.09.015.
Cell. 2015.
PMID: 26406374
Free PMC article.
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Effects of Mutations on the Aggregation Propensity of the Human Prion-Like Protein hnRNPA2B1.
Paul KR, Molliex A, Cascarina S, Boncella AE, Taylor JP, Ross ED.
Paul KR, et al.
Mol Cell Biol. 2017 Mar 31;37(8):e00652-16. doi: 10.1128/MCB.00652-16. Print 2017 Apr 15.
Mol Cell Biol. 2017.
PMID: 28137911
Free PMC article.
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C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles.
Lee KH, Zhang P, Kim HJ, Mitrea DM, Sarkar M, Freibaum BD, Cika J, Coughlin M, Messing J, Molliex A, Maxwell BA, Kim NC, Temirov J, Moore J, Kolaitis RM, Shaw TI, Bai B, Peng J, Kriwacki RW, Taylor JP.
Lee KH, et al.
Cell. 2016 Oct 20;167(3):774-788.e17. doi: 10.1016/j.cell.2016.10.002.
Cell. 2016.
PMID: 27768896
Free PMC article.
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Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.
Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, Pinkus JL, Greenberg SA, Trojanowski JQ, Traynor BJ, Smith BN, Topp S, Gkazi AS, Miller J, Shaw CE, Kottlors M, Kirschner J, Pestronk A, Li YR, Ford AF, Gitler AD, Benatar M, King OD, Kimonis VE, Ross ED, Weihl CC, Shorter J, Taylor JP.
Kim HJ, et al. Among authors: molliex a.
Nature. 2013 Mar 28;495(7442):467-73. doi: 10.1038/nature11922. Epub 2013 Mar 3.
Nature. 2013.
PMID: 23455423
Free PMC article.
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Genetic interaction of hnRNPA2B1 and DNAJB6 in a Drosophila model of multisystem proteinopathy.
Li S, Zhang P, Freibaum BD, Kim NC, Kolaitis RM, Molliex A, Kanagaraj AP, Yabe I, Tanino M, Tanaka S, Sasaki H, Ross ED, Taylor JP, Kim HJ.
Li S, et al.
Hum Mol Genet. 2016 Mar 1;25(5):936-50. doi: 10.1093/hmg/ddv627. Epub 2016 Jan 6.
Hum Mol Genet. 2016.
PMID: 26744327
Free PMC article.
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VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations.
Kim NC, Tresse E, Kolaitis RM, Molliex A, Thomas RE, Alami NH, Wang B, Joshi A, Smith RB, Ritson GP, Winborn BJ, Moore J, Lee JY, Yao TP, Pallanck L, Kundu M, Taylor JP.
Kim NC, et al.
Neuron. 2013 Apr 10;78(1):65-80. doi: 10.1016/j.neuron.2013.02.029. Epub 2013 Mar 14.
Neuron. 2013.
PMID: 23498974
Free PMC article.
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Mitotic memories of gene activity.
Gonzalez I, Molliex A, Navarro P.
Gonzalez I, et al.
Curr Opin Cell Biol. 2021 Apr;69:41-47. doi: 10.1016/j.ceb.2020.12.009. Epub 2021 Jan 14.
Curr Opin Cell Biol. 2021.
PMID: 33454629
Review.
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