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The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases.
Nat Commun. 2023 Oct 27;14(1):6750. doi: 10.1038/s41467-023-42305-3.
Nat Commun. 2023.
PMID: 37891183
Free PMC article.
Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies.
Kroth H, Oden F, Molette J, Schieferstein H, Capotosti F, Mueller A, Berndt M, Schmitt-Willich H, Darmency V, Gabellieri E, Boudou C, Juergens T, Varisco Y, Vokali E, Hickman DT, Tamagnan G, Pfeifer A, Dinkelborg L, Muhs A, Stephens A.
Kroth H, et al. Among authors: molette j.
Eur J Nucl Med Mol Imaging. 2019 Sep;46(10):2178-2189. doi: 10.1007/s00259-019-04397-2. Epub 2019 Jul 1.
Eur J Nucl Med Mol Imaging. 2019.
PMID: 31264169
Free PMC article.
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Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core.
Kroth H, Oden F, Serra AM, Molette J, Mueller A, Berndt M, Capotosti F, Gabellieri E, Schmitt-Willich H, Hickman D, Pfeifer A, Dinkelborg L, Stephens A.
Kroth H, et al. Among authors: molette j.
Bioorg Med Chem. 2021 Dec 15;52:116528. doi: 10.1016/j.bmc.2021.116528. Epub 2021 Nov 20.
Bioorg Med Chem. 2021.
PMID: 34839158
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PI-2620 Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer's Disease and Other Tauopathies.
Kroth H, Oden F, Molette J, Schieferstein H, Gabellieri E, Mueller A, Berndt M, Sreenivasachary N, Serra AM, Capotosti F, Schmitt-Willich H, Hickman D, Pfeifer A, Dinkelborg L, Stephens A.
Kroth H, et al. Among authors: molette j.
J Med Chem. 2021 Sep 9;64(17):12808-12830. doi: 10.1021/acs.jmedchem.1c00861. Epub 2021 Aug 29.
J Med Chem. 2021.
PMID: 34455780
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Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies.
Gabellieri E, Capotosti F, Molette J, Sreenivasachary N, Mueller A, Berndt M, Schieferstein H, Juergens T, Varisco Y, Oden F, Schmitt-Willich H, Hickman D, Dinkelborg L, Stephens A, Pfeifer A, Kroth H.
Gabellieri E, et al. Among authors: molette j.
Eur J Med Chem. 2020 Oct 15;204:112615. doi: 10.1016/j.ejmech.2020.112615. Epub 2020 Jul 15.
Eur J Med Chem. 2020.
PMID: 32771872
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Identification and optimization of an aminoalcohol-carbazole series with antimalarial properties.
Molette J, Routier J, Abla N, Besson D, Bombrun A, Brun R, Burt H, Georgi K, Kaiser M, Nwaka S, Muzerelle M, Scheer A.
Molette J, et al.
ACS Med Chem Lett. 2013 Sep 22;4(11):1037-41. doi: 10.1021/ml400015f. eCollection 2013 Nov 14.
ACS Med Chem Lett. 2013.
PMID: 24900603
Free PMC article.
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Acidic triazoles as soluble guanylate cyclase stimulators.
Roberts LR, Bradley PA, Bunnage ME, England KS, Fairman D, Fobian YM, Fox DN, Gymer GE, Heasley SE, Molette J, Smith GL, Schmidt MA, Tones MA, Dack KN.
Roberts LR, et al. Among authors: molette j.
Bioorg Med Chem Lett. 2011 Nov 1;21(21):6515-8. doi: 10.1016/j.bmcl.2011.08.071. Epub 2011 Aug 28.
Bioorg Med Chem Lett. 2011.
PMID: 21924901
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