Moles A - Search Results

1

The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease.

Cocchiaro P, De Pasquale V, Della Morte R, Tafuri S, Avallone L, Pizard A, Moles A, Pavone LM. Cocchiaro P, et al. Among authors: moles a. Front Cell Dev Biol. 2017 Dec 19;5:114. doi: 10.3389/fcell.2017.00114. eCollection 2017. Front Cell Dev Biol. 2017. PMID: 29312937 Free PMC article. Review.

2

Inhibition of lysosomal protease cathepsin D reduces renal fibrosis in murine chronic kidney disease.

Fox C, Cocchiaro P, Oakley F, Howarth R, Callaghan K, Leslie J, Luli S, Wood KM, Genovese F, Sheerin NS, Moles A. Fox C, et al. Among authors: moles a. Sci Rep. 2016 Feb 2;6:20101. doi: 10.1038/srep20101. Sci Rep. 2016. PMID: 26831567 Free PMC article.

3

Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury.

Cocchiaro P, Fox C, Tregidgo NW, Howarth R, Wood KM, Situmorang GR, Pavone LM, Sheerin NS, Moles A. Cocchiaro P, et al. Among authors: moles a. Sci Rep. 2016 Jun 7;6:27112. doi: 10.1038/srep27112. Sci Rep. 2016. PMID: 27271556 Free PMC article.

4

Cathepsins in the Pathophysiology of Mucopolysaccharidoses: New Perspectives for Therapy.

De Pasquale V, Moles A, Pavone LM. De Pasquale V, et al. Among authors: moles a. Cells. 2020 Apr 15;9(4):979. doi: 10.3390/cells9040979. Cells. 2020. PMID: 32326609 Free PMC article. Review.

5

The multifaceted role of cathepsins in liver disease.

Ruiz-Blázquez P, Pistorio V, Fernández-Fernández M, Moles A. Ruiz-Blázquez P, et al. Among authors: moles a. J Hepatol. 2021 Nov;75(5):1192-1202. doi: 10.1016/j.jhep.2021.06.031. Epub 2021 Jul 7. J Hepatol. 2021. PMID: 34242696 Free article. Review.

6

Mitochondrial-Lysosomal Axis in Acetaminophen Hepatotoxicity.

Moles A, Torres S, Baulies A, Garcia-Ruiz C, Fernandez-Checa JC. Moles A, et al. Front Pharmacol. 2018 May 15;9:453. doi: 10.3389/fphar.2018.00453. eCollection 2018. Front Pharmacol. 2018. PMID: 29867464 Free PMC article. Review.

7

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis.

Martínez-Fábregas J, Prescott A, van Kasteren S, Pedrioli DL, McLean I, Moles A, Reinheckel T, Poli V, Watts C. Martínez-Fábregas J, et al. Among authors: moles a. Nat Commun. 2018 Dec 17;9(1):5343. doi: 10.1038/s41467-018-07741-6. Nat Commun. 2018. PMID: 30559339 Free PMC article.

8

Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation.

de Mingo Á, de Gregorio E, Moles A, Tarrats N, Tutusaus A, Colell A, Fernandez-Checa JC, Morales A, Marí M. de Mingo Á, et al. Among authors: moles a. Cell Death Dis. 2016 Nov 10;7(11):e2464. doi: 10.1038/cddis.2016.368. Cell Death Dis. 2016. PMID: 27831566 Free PMC article.

9

Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response.

Moles A, Sanchez AM, Banks PS, Murphy LB, Luli S, Borthwick L, Fisher A, O'Reilly S, van Laar JM, White SA, Perkins ND, Burt AD, Mann DA, Oakley F. Moles A, et al. Hepatology. 2013 Feb;57(2):817-28. doi: 10.1002/hep.26068. Epub 2013 Jan 8. Hepatology. 2013. PMID: 22996371 Free PMC article.

10

The NF-κB1 is a key regulator of acute but not chronic renal injury.

Fearn A, Situmorang GR, Fox C, Oakley F, Howarth R, Wilson CL, Kiosia A, Robson MG, Mann DA, Moles A, Sheerin NS. Fearn A, et al. Among authors: moles a. Cell Death Dis. 2017 Jun 15;8(6):e2883. doi: 10.1038/cddis.2017.233. Cell Death Dis. 2017. PMID: 28617440 Free PMC article.

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