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Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress.
Lenting K, Khurshed M, Peeters TH, van den Heuvel CNAM, van Lith SAM, de Bitter T, Hendriks W, Span PN, Molenaar RJ, Botman D, Verrijp K, Heerschap A, Ter Laan M, Kusters B, van Ewijk A, Huynen MA, van Noorden CJF, Leenders WPJ. Lenting K, et al. Among authors: molenaar rj. FASEB J. 2019 Jan;33(1):557-571. doi: 10.1096/fj.201800907RR. Epub 2018 Jul 12. FASEB J. 2019. PMID: 30001166
The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone.
Molenaar RJ, Verbaan D, Lamba S, Zanon C, Jeuken JW, Boots-Sprenger SH, Wesseling P, Hulsebos TJ, Troost D, van Tilborg AA, Leenstra S, Vandertop WP, Bardelli A, van Noorden CJ, Bleeker FE. Molenaar RJ, et al. Neuro Oncol. 2014 Sep;16(9):1263-73. doi: 10.1093/neuonc/nou005. Epub 2014 Feb 6. Neuro Oncol. 2014. PMID: 24510240 Free PMC article.
Type 2 diabetes and cancer as redox diseases?
Molenaar RJ, van Noorden CJ. Molenaar RJ, et al. Lancet. 2014 Sep 6;384(9946):853. doi: 10.1016/S0140-6736(14)61485-9. Lancet. 2014. PMID: 25209484 No abstract available.
Mutational profiling of kinases in glioblastoma.
Bleeker FE, Lamba S, Zanon C, Molenaar RJ, Hulsebos TJ, Troost D, van Tilborg AA, Vandertop WP, Leenstra S, van Noorden CJ, Bardelli A. Bleeker FE, et al. Among authors: molenaar rj. BMC Cancer. 2014 Sep 26;14:718. doi: 10.1186/1471-2407-14-718. BMC Cancer. 2014. PMID: 25256166 Free PMC article.
Radioprotection of IDH1-Mutated Cancer Cells by the IDH1-Mutant Inhibitor AGI-5198.
Molenaar RJ, Botman D, Smits MA, Hira VV, van Lith SA, Stap J, Henneman P, Khurshed M, Lenting K, Mul AN, Dimitrakopoulou D, van Drunen CM, Hoebe RA, Radivoyevitch T, Wilmink JW, Maciejewski JP, Vandertop WP, Leenders WP, Bleeker FE, van Noorden CJ. Molenaar RJ, et al. Cancer Res. 2015 Nov 15;75(22):4790-802. doi: 10.1158/0008-5472.CAN-14-3603. Epub 2015 Sep 11. Cancer Res. 2015. PMID: 26363012
77 results