Mole DR - Search Results

1

Oncogenic cell tagging and single-cell transcriptomics reveal cell type-specific and time-resolved responses to Vhl inactivation in the kidney.

Kurlekar S, Lima JDCC, Li R, Lombardi O, Masson N, Barros AB, Pontecorvi V, Mole DR, Pugh CW, Adam J, Ratcliffe PJ. Kurlekar S, et al. Among authors: mole dr. Cancer Res. 2024 Mar 19. doi: 10.1158/0008-5472.CAN-23-3248. Online ahead of print. Cancer Res. 2024. PMID: 38502859

2

Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1.

Knowles HJ, Mole DR, Ratcliffe PJ, Harris AL. Knowles HJ, et al. Among authors: mole dr. Cancer Res. 2006 Mar 1;66(5):2600-7. doi: 10.1158/0008-5472.CAN-05-2351. Cancer Res. 2006. PMID: 16510578

3

Co-incidence of RCC-susceptibility polymorphisms with HIF cis-acting sequences supports a pathway tuning model of cancer.

Schmid V, Lafleur VN, Lombardi O, Li R, Salama R, Colli L, Choudhry H, Chanock S, Ratcliffe PJ, Mole DR. Schmid V, et al. Among authors: mole dr. Sci Rep. 2019 Dec 10;9(1):18768. doi: 10.1038/s41598-019-55098-7. Sci Rep. 2019. PMID: 31822727 Free PMC article.

4

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.

Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH. Cockman ME, et al. Among authors: mole dr. J Biol Chem. 2000 Aug 18;275(33):25733-41. doi: 10.1074/jbc.M002740200. J Biol Chem. 2000. PMID: 10823831 Free article.

5

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.

Mole DR, Maxwell PH, Pugh CW, Ratcliffe PJ. Mole DR, et al. IUBMB Life. 2001 Jul;52(1-2):43-7. doi: 10.1080/15216540252774757. IUBMB Life. 2001. PMID: 11795592 Free article. Review.

6

Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis.

Couvé S, Ladroue C, Laine E, Mahtouk K, Guégan J, Gad S, Le Jeune H, Le Gentil M, Nuel G, Kim WY, Lecomte B, Pagès JC, Collin C, Lasne F, Benusiglio PR, Bressac-de Paillerets B, Feunteun J, Lazar V, Gimenez-Roqueplo AP, Mazure NM, Dessen P, Tchertanov L, Mole DR, Kaelin W, Ratcliffe P, Richard S, Gardie B. Couvé S, et al. Among authors: mole dr. Cancer Res. 2014 Nov 15;74(22):6554-64. doi: 10.1158/0008-5472.CAN-14-1161. Epub 2014 Nov 4. Cancer Res. 2014. PMID: 25371412 Free PMC article.

7

Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer.

Salama R, Masson N, Simpson P, Sciesielski LK, Sun M, Tian YM, Ratcliffe PJ, Mole DR. Salama R, et al. Among authors: mole dr. PLoS One. 2015 Aug 11;10(8):e0134645. doi: 10.1371/journal.pone.0134645. eCollection 2015. PLoS One. 2015. PMID: 26262842 Free PMC article.

8

Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)-mediated induction of the long noncoding RNA NICI.

Lauer V, Grampp S, Platt J, Lafleur V, Lombardi O, Choudhry H, Kranz F, Hartmann A, Wullich B, Yamamoto A, Coleman ML, Ratcliffe PJ, Mole DR, Schödel J. Lauer V, et al. Among authors: mole dr. J Biol Chem. 2020 Mar 27;295(13):4065-4078. doi: 10.1074/jbc.RA119.009827. Epub 2019 Nov 5. J Biol Chem. 2020. PMID: 31690629 Free PMC article.

9

Cellular oxygen sensing in health and disease.

Mole DR, Ratcliffe PJ. Mole DR, et al. Pediatr Nephrol. 2008 May;23(5):681-94. doi: 10.1007/s00467-007-0632-x. Epub 2007 Oct 23. Pediatr Nephrol. 2008. PMID: 17955264 Review.

10

Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.

Lakhal S, Schödel J, Townsend AR, Pugh CW, Ratcliffe PJ, Mole DR. Lakhal S, et al. Among authors: mole dr. J Biol Chem. 2011 Feb 11;286(6):4090-7. doi: 10.1074/jbc.M110.173096. Epub 2010 Oct 21. J Biol Chem. 2011. PMID: 20966077 Free PMC article.

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