Mohr K - Search Results

1

Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors.

Tränkle C, Dittmann A, Schulz U, Weyand O, Buller S, Jöhren K, Heller E, Birdsall NJ, Holzgrabe U, Ellis J, Höltje HD, Mohr K. Tränkle C, et al. Among authors: mohr k. Mol Pharmacol. 2005 Dec;68(6):1597-610. doi: 10.1124/mol.105.017707. Epub 2005 Sep 12. Mol Pharmacol. 2005. PMID: 16157694

2

Allosteric site on muscarinic acetylcholine receptors: a single amino acid in transmembrane region 7 is critical to the subtype selectivities of caracurine V derivatives and alkane-bisammonium ligands.

Buller S, Zlotos DP, Mohr K, Ellis J. Buller S, et al. Among authors: mohr k. Mol Pharmacol. 2002 Jan;61(1):160-8. doi: 10.1124/mol.61.1.160. Mol Pharmacol. 2002. PMID: 11752217

3

Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupied receptors.

Voigtländer U, Jöhren K, Mohr M, Raasch A, Tränkle C, Buller S, Ellis J, Höltje HD, Mohr K. Voigtländer U, et al. Among authors: mohr m, mohr k. Mol Pharmacol. 2003 Jul;64(1):21-31. doi: 10.1124/mol.64.1.21. Mol Pharmacol. 2003. PMID: 12815157

4

Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.

Tränkle C, Weyand O, Voigtländer U, Mynett A, Lazareno S, Birdsall NJ, Mohr K. Tränkle C, et al. Among authors: mohr k. Mol Pharmacol. 2003 Jul;64(1):180-90. doi: 10.1124/mol.64.1.180. Mol Pharmacol. 2003. PMID: 12815174

5

Contribution of lateral substituents in symmetrical and non-symmetrical heptane-bisammonio compounds to the allosteric stabilization of N-methylscopolamine binding to muscarinic M2 receptors.

Staudt M, Tränkle C, Mohr K, Holzgrabe U. Staudt M, et al. Among authors: mohr k. Arch Pharm (Weinheim). 2003 Aug;336(8):385-9. doi: 10.1002/ardp.200300747. Arch Pharm (Weinheim). 2003. PMID: 14502759

6

Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist.

Grossmüller M, Antony J, Tränkle C, Holzgrabe U, Mohr K. Grossmüller M, et al. Among authors: mohr k. Naunyn Schmiedebergs Arch Pharmacol. 2006 Jan;372(4):267-76. doi: 10.1007/s00210-005-0023-4. Epub 2005 Dec 16. Naunyn Schmiedebergs Arch Pharmacol. 2006. PMID: 16362429

7

Muscarinic allosteric modulators: atypical structure-activity-relationships in bispyridinium-type compounds.

Sürig U, Gaal K, Kostenis E, Tränkle C, Mohr K, Holzgrabe U. Sürig U, et al. Among authors: mohr k. Arch Pharm (Weinheim). 2006 Apr;339(4):207-12. doi: 10.1002/ardp.200600005. Arch Pharm (Weinheim). 2006. PMID: 16572483

8

Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity.

Prilla S, Schrobang J, Ellis J, Höltje HD, Mohr K. Prilla S, et al. Among authors: mohr k. Mol Pharmacol. 2006 Jul;70(1):181-93. doi: 10.1124/mol.106.023481. Epub 2006 Apr 26. Mol Pharmacol. 2006. PMID: 16641315

9

Allosteric modulators and selective agonists of muscarinic receptors.

Holzgrabe U, De Amici M, Mohr K. Holzgrabe U, et al. Among authors: mohr k. J Mol Neurosci. 2006;30(1-2):165-8. doi: 10.1385/JMN:30:1:165. J Mol Neurosci. 2006. PMID: 17192667

10

Rational design of dualsteric GPCR ligands: quests and promise.

Mohr K, Tränkle C, Kostenis E, Barocelli E, De Amici M, Holzgrabe U. Mohr K, et al. Br J Pharmacol. 2010 Mar;159(5):997-1008. doi: 10.1111/j.1476-5381.2009.00601.x. Epub 2010 Feb 5. Br J Pharmacol. 2010. PMID: 20136835 Free PMC article. Review.

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