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Aging negatively impacts the ability of megakaryocytes to stimulate osteoblast proliferation and bone mass.
Maupin KA, Himes ER, Plett AP, Chua HL, Singh P, Ghosh J, Mohamad SF, Abeysekera I, Fisher A, Sampson C, Hong JM, Childress P, Alvarez M, Srour EF, Bruzzaniti A, Pelus LM, Orschell CM, Kacena MA. Maupin KA, et al. Among authors: mohamad sf. Bone. 2019 Oct;127:452-459. doi: 10.1016/j.bone.2019.07.010. Epub 2019 Jul 9. Bone. 2019. PMID: 31299382 Free PMC article.
Megakaryocyte and Osteoblast Interactions Modulate Bone Mass and Hematopoiesis.
Alvarez MB, Xu L, Childress PJ, Maupin KA, Mohamad SF, Chitteti BR, Himes E, Olivos DJ 3rd, Cheng YH, Conway SJ, Srour EF, Kacena MA. Alvarez MB, et al. Among authors: mohamad sf. Stem Cells Dev. 2018 May 15;27(10):671-682. doi: 10.1089/scd.2017.0178. Stem Cells Dev. 2018. PMID: 29631496 Free PMC article.
Megakaryocytes promote osteoclastogenesis in aging.
Kanagasabapathy D, Blosser RJ, Maupin KA, Hong JM, Alvarez M, Ghosh J, Mohamad SF, Aguilar-Perez A, Srour EF, Kacena MA, Bruzzaniti A. Kanagasabapathy D, et al. Among authors: mohamad sf. Aging (Albany NY). 2020 Jul 7;12(14):15121-15133. doi: 10.18632/aging.103595. Epub 2020 Jul 7. Aging (Albany NY). 2020. PMID: 32634116 Free PMC article.
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