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Regulatory T cells promote myelin regeneration in the central nervous system.
Dombrowski Y, O'Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan JR, Franklin RJM, Fitzgerald DC. Dombrowski Y, et al. Among authors: moffat j. Nat Neurosci. 2017 May;20(5):674-680. doi: 10.1038/nn.4528. Epub 2017 Mar 13. Nat Neurosci. 2017. PMID: 28288125 Free PMC article.
Dynamic CCN3 expression in the murine CNS does not confer essential roles in myelination or remyelination.
de la Vega Gallardo N, Penalva R, Dittmer M, Naughton M, Falconer J, Moffat J, de la Fuente AG, Hombrebueno JR, Lin Z, Perbal B, Ingram RJ, Evergren E, Fitzgerald DC. de la Vega Gallardo N, et al. Among authors: moffat j. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):18018-18028. doi: 10.1073/pnas.1922089117. Epub 2020 Jul 10. Proc Natl Acad Sci U S A. 2020. PMID: 32651278 Free PMC article.
CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis.
Naughton M, Moffat J, Eleftheriadis G, de la Vega Gallardo N, Young A, Falconer J, Hawkins K, Pearson B, Perbal B, Hogan A, Moynagh P, Loveless S, Robertson NP, Gran B, Kee R, Hughes S, McDonnell G, Howell O, Fitzgerald DC. Naughton M, et al. Among authors: moffat j. J Neuroinflammation. 2020 Nov 22;17(1):349. doi: 10.1186/s12974-020-02025-7. J Neuroinflammation. 2020. PMID: 33222687 Free PMC article.
Reduced Cone Density Is Associated with Multiple Sclerosis.
McIlwaine G, Csincsik L, Coey R, Wang L, Fitzgerald D, Moffat J, Dubis AM, McDonnell G, Hughes S, Peto T, Lengyel I. McIlwaine G, et al. Among authors: moffat j. Ophthalmol Sci. 2023 Apr 13;3(3):100308. doi: 10.1016/j.xops.2023.100308. eCollection 2023 Sep. Ophthalmol Sci. 2023. PMID: 37214765 Free PMC article.
Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids.
Dhaliwal NK, Weng OY, Dong X, Bhattacharya A, Ahmed M, Nishimura H, Choi WWY, Aggarwal A, Luikart BW, Shu Q, Li X, Wilson MD, Moffat J, Wang LY, Muffat J, Li Y. Dhaliwal NK, et al. Among authors: moffat j. Cell Rep. 2024 May 2;43(5):114173. doi: 10.1016/j.celrep.2024.114173. Online ahead of print. Cell Rep. 2024. PMID: 38700984 Free article.
Synthesis of LAVR-289, a new [(Z)-3-(acetoxymethyl)-4-(2,4-diaminopyrimidin-6-yl)oxy-but-2-enyl]phosphonic acid prodrug with pronounced antiviral activity against DNA viruses.
Bessières M, Roy V, Abuduani T, Favetta P, Snoeck R, Andrei G, Moffat J, Gallardo F, Agrofoglio LA. Bessières M, et al. Among authors: moffat j. Eur J Med Chem. 2024 May 5;271:116412. doi: 10.1016/j.ejmech.2024.116412. Epub 2024 Apr 15. Eur J Med Chem. 2024. PMID: 38643669 Free article.
Salmonella exploits membrane reservoirs for invasion of host cells.
Zhu H, Sydor AM, Boddy KC, Coyaud E, Laurent EMN, Au A, Tan JMJ, Yan BR, Moffat J, Muise AM, Yip CM, Grinstein S, Raught B, Brumell JH. Zhu H, et al. Among authors: moffat j. Nat Commun. 2024 Apr 10;15(1):3120. doi: 10.1038/s41467-024-47183-x. Nat Commun. 2024. PMID: 38600106 Free PMC article.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.
Lü Y, Cho T, Mukherjee S, Suarez CF, Gonzalez-Foutel NS, Malik A, Martinez S, Dervovic D, Oh RH, Langille E, Al-Zahrani KN, Hoeg L, Lin ZY, Tsai R, Mbamalu G, Rotter V, Ashton-Prolla P, Moffat J, Chemes LB, Gingras AC, Oren M, Durocher D, Schramek D. Lü Y, et al. Among authors: moffat j. Mol Syst Biol. 2024 Apr 5. doi: 10.1038/s44320-024-00032-x. Online ahead of print. Mol Syst Biol. 2024. PMID: 38580884 Free article.
467 results