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ZB-06, a vaginal film containing an engineered human contraceptive antibody (HC4-N), demonstrates safety and efficacy in a phase 1 postcoital test and safety study.
Thurman AR, Moench TR, Hoke M, Politch JA, Cabral H, Mausser E, Nador E, Morton J, Hamorsky K, Swope K, Bratcher B, Anderson DJ, Whaley KJ. Thurman AR, et al. Among authors: moench tr. Am J Obstet Gynecol. 2023 Jun;228(6):716.e1-716.e12. doi: 10.1016/j.ajog.2023.02.024. Epub 2023 Mar 2. Am J Obstet Gynecol. 2023. PMID: 36870409 Free article. Clinical Trial.
Inhaled "Muco-Trapping" Monoclonal Antibody Effectively Treats Established Respiratory Syncytial Virus (RSV) Infections.
McSweeney MD, Alnajjar S, Schaefer AM, Richardson Z, Wolf W, Stewart I, Sriboonyapirat P, McCallen J, Farmer E, Nzati B, Lord S, Farrer B, Moench TR, Kumar PA, Arora H, Pickles RJ, Hickey AJ, Ackermann M, Lai SK. McSweeney MD, et al. Among authors: moench tr. Adv Sci (Weinh). 2024 Mar;11(12):e2306729. doi: 10.1002/advs.202306729. Epub 2024 Jan 15. Adv Sci (Weinh). 2024. PMID: 38225749 Free PMC article.
Hexavalent sperm-binding IgG antibody released from vaginal film for development of potent on-demand nonhormonal female contraception.
Shrestha B, Vincent K, Schaefer A, Zhu Y, Vargas G, Motamedi M, Swope K, Morton J, Simpson C, Pham H, Brennan MB, Pauly MH, Zeitlin L, Bratcher B, Whaley KJ, Moench TR, Lai SK. Shrestha B, et al. Among authors: moench tr. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2107832118. doi: 10.1073/pnas.2107832118. Proc Natl Acad Sci U S A. 2021. PMID: 34815336 Free PMC article.
Safety, acceptability, and pharmacokinetics of a monoclonal antibody-based vaginal multipurpose prevention film (MB66): A Phase I randomized trial.
Politch JA, Cu-Uvin S, Moench TR, Tashima KT, Marathe JG, Guthrie KM, Cabral H, Nyhuis T, Brennan M, Zeitlin L, Spiegel HML, Mayer KH, Whaley KJ, Anderson DJ. Politch JA, et al. Among authors: moench tr. PLoS Med. 2021 Feb 3;18(2):e1003495. doi: 10.1371/journal.pmed.1003495. eCollection 2021 Feb. PLoS Med. 2021. PMID: 33534791 Free PMC article. Clinical Trial.
The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis.
Hoang T, Toler E, DeLong K, Mafunda NA, Bloom SM, Zierden HC, Moench TR, Coleman JS, Hanes J, Kwon DS, Lai SK, Cone RA, Ensign LM. Hoang T, et al. Among authors: moench tr. PLoS Pathog. 2020 Jan 23;16(1):e1008236. doi: 10.1371/journal.ppat.1008236. eCollection 2020 Jan. PLoS Pathog. 2020. PMID: 31971984 Free PMC article.
74 results