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LRRK2 inhibition attenuates microglial inflammatory responses.
Moehle MS, Webber PJ, Tse T, Sukar N, Standaert DG, DeSilva TM, Cowell RM, West AB. Moehle MS, et al. J Neurosci. 2012 Feb 1;32(5):1602-11. doi: 10.1523/JNEUROSCI.5601-11.2012. J Neurosci. 2012. PMID: 22302802 Free PMC article.
LRRK2 secretion in exosomes is regulated by 14-3-3.
Fraser KB, Moehle MS, Daher JP, Webber PJ, Williams JY, Stewart CA, Yacoubian TA, Cowell RM, Dokland T, Ye T, Chen D, Siegal GP, Galemmo RA, Tsika E, Moore DJ, Standaert DG, Kojima K, Mobley JA, West AB. Fraser KB, et al. Among authors: moehle ms. Hum Mol Genet. 2013 Dec 15;22(24):4988-5000. doi: 10.1093/hmg/ddt346. Epub 2013 Jul 25. Hum Mol Genet. 2013. PMID: 23886663 Free PMC article.
Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.
Liu Z, Galemmo RA Jr, Fraser KB, Moehle MS, Sen S, Volpicelli-Daley LA, DeLucas LJ, Ross LJ, Valiyaveettil J, Moukha-Chafiq O, Pathak AK, Ananthan S, Kezar H, White EL, Gupta V, Maddry JA, Suto MJ, West AB. Liu Z, et al. Among authors: moehle ms. J Biol Chem. 2014 Nov 21;289(47):32937-51. doi: 10.1074/jbc.M114.602318. Epub 2014 Sep 16. J Biol Chem. 2014. PMID: 25228699 Free PMC article.
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