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Neuronal human BACE1 knockin induces systemic diabetes in mice.
Plucińska K, Dekeryte R, Koss D, Shearer K, Mody N, Whitfield PD, Doherty MK, Mingarelli M, Welch A, Riedel G, Delibegovic M, Platt B. Plucińska K, et al. Among authors: mody n. Diabetologia. 2016 Jul;59(7):1513-1523. doi: 10.1007/s00125-016-3960-1. Epub 2016 May 2. Diabetologia. 2016. PMID: 27138913 Free PMC article.
Susceptibility to diet-induced obesity and glucose intolerance in the APP (SWE)/PSEN1 (A246E) mouse model of Alzheimer's disease is associated with increased brain levels of protein tyrosine phosphatase 1B (PTP1B) and retinol-binding protein 4 (RBP4), and basal phosphorylation of S6 ribosomal protein.
Mody N, Agouni A, McIlroy GD, Platt B, Delibegovic M. Mody N, et al. Diabetologia. 2011 Aug;54(8):2143-51. doi: 10.1007/s00125-011-2160-2. Epub 2011 May 3. Diabetologia. 2011. PMID: 21538175
Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.
Owen C, Czopek A, Agouni A, Grant L, Judson R, Lees EK, Mcilroy GD, Göransson O, Welch A, Bence KK, Kahn BB, Neel BG, Mody N, Delibegović M. Owen C, et al. Among authors: mody n. PLoS One. 2012;7(2):e32700. doi: 10.1371/journal.pone.0032700. Epub 2012 Feb 28. PLoS One. 2012. PMID: 22389718 Free PMC article.
Myeloid-cell protein tyrosine phosphatase-1B deficiency in mice protects against high-fat diet and lipopolysaccharide-induced inflammation, hyperinsulinemia, and endotoxemia through an IL-10 STAT3-dependent mechanism.
Grant L, Shearer KD, Czopek A, Lees EK, Owen C, Agouni A, Workman J, Martin-Granados C, Forrester JV, Wilson HM, Mody N, Delibegovic M. Grant L, et al. Among authors: mody n. Diabetes. 2014 Feb;63(2):456-70. doi: 10.2337/db13-0885. Epub 2013 Nov 1. Diabetes. 2014. PMID: 24186864
128 results