Mochizuki T - Search Results

1

Physiologically-based pharmacokinetic model-based translation of OATP1B-mediated drug-drug interactions from coproporphyrin I to probe drugs.

Mochizuki T, Aoki Y, Yoshikado T, Yoshida K, Lai Y, Hirabayashi H, Yamaura Y, Rockich K, Taskar K, Takashima T, Chu X, Zamek-Gliszczynski MJ, Mao J, Maeda K, Furihata K, Sugiyama Y, Kusuhara H. Mochizuki T, et al. Clin Transl Sci. 2022 Jun;15(6):1519-1531. doi: 10.1111/cts.13272. Epub 2022 May 2. Clin Transl Sci. 2022. PMID: 35421902 Free PMC article.

2

Involvement of Organic Cation Transporters in the Kinetics of Trimethylamine N-oxide.

Miyake T, Mizuno T, Mochizuki T, Kimura M, Matsuki S, Irie S, Ieiri I, Maeda K, Kusuhara H. Miyake T, et al. Among authors: mochizuki t. J Pharm Sci. 2017 Sep;106(9):2542-2550. doi: 10.1016/j.xphs.2017.04.067. Epub 2017 May 4. J Pharm Sci. 2017. PMID: 28479364

3

Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier.

Sano Y, Mizuno T, Mochizuki T, Uchida Y, Umetsu M, Terasaki T, Kusuhara H. Sano Y, et al. Among authors: mochizuki t. Drug Metab Dispos. 2018 Nov;46(11):1767-1775. doi: 10.1124/dmd.118.081877. Epub 2018 Aug 28. Drug Metab Dispos. 2018. PMID: 30154106

4

Expression and Functional Characterization of Drug Transporters in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.

Kurosawa T, Tega Y, Higuchi K, Yamaguchi T, Nakakura T, Mochizuki T, Kusuhara H, Kawabata K, Deguchi Y. Kurosawa T, et al. Among authors: mochizuki t. Mol Pharm. 2018 Dec 3;15(12):5546-5555. doi: 10.1021/acs.molpharmaceut.8b00697. Epub 2018 Nov 12. Mol Pharm. 2018. PMID: 30376629

5

Elucidation of N ¹-methyladenosine as a Potential Surrogate Biomarker for Drug Interaction Studies Involving Renal Organic Cation Transporters.

Miyake T, Mizuno T, Takehara I, Mochizuki T, Kimura M, Matsuki S, Irie S, Watanabe N, Kato Y, Ieiri I, Maeda K, Ando O, Kusuhara H. Miyake T, et al. Among authors: mochizuki t. Drug Metab Dispos. 2019 Nov;47(11):1270-1280. doi: 10.1124/dmd.119.087262. Epub 2019 Sep 11. Drug Metab Dispos. 2019. PMID: 31511257

6

Functional Investigation of Solute Carrier Family 35, Member F2, in Three Cellular Models of the Primate Blood-Brain Barrier.

Mochizuki T, Mizuno T, Kurosawa T, Yamaguchi T, Higuchi K, Tega Y, Nozaki Y, Kawabata K, Deguchi Y, Kusuhara H. Mochizuki T, et al. Drug Metab Dispos. 2021 Jan;49(1):3-11. doi: 10.1124/dmd.120.000115. Epub 2020 Nov 3. Drug Metab Dispos. 2021. PMID: 33144341

7

Current progress in identifying endogenous biomarker candidates for drug transporter phenotyping and their potential application to drug development.

Mochizuki T, Mizuno T, Maeda K, Kusuhara H. Mochizuki T, et al. Drug Metab Pharmacokinet. 2021 Apr;37:100358. doi: 10.1016/j.dmpk.2020.09.003. Epub 2020 Sep 22. Drug Metab Pharmacokinet. 2021. PMID: 33461054 Review.

8

Transport Characteristics of 6-Mercaptopurine in Brain Microvascular Endothelial Cells Derived From Human Induced Pluripotent Stem Cells.

Kurosawa T, Tega Y, Sako D, Mochizuki T, Yamaguchi T, Kawabata K, Inoue K, Ito N, Kusuhara H, Deguchi Y. Kurosawa T, et al. Among authors: mochizuki t. J Pharm Sci. 2021 Oct;110(10):3484-3490. doi: 10.1016/j.xphs.2021.06.007. Epub 2021 Jun 5. J Pharm Sci. 2021. PMID: 34102205

9

Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions.

Mochizuki T, Zamek-Gliszczynski MJ, Yoshida K, Mao J, Taskar K, Hirabayashi H, Chu X, Lai Y, Takashima T, Rockich K, Yamaura Y, Fujiwara K, Mizuno T, Maeda K, Furihata K, Sugiyama Y, Kusuhara H. Mochizuki T, et al. Clin Pharmacol Ther. 2022 Jun;111(6):1315-1323. doi: 10.1002/cpt.2584. Epub 2022 Apr 11. Clin Pharmacol Ther. 2022. PMID: 35292967 Free PMC article.

10

Cluster Gauss-Newton method analyses of PBPK model parameter combinations of coproporphyrin-I based on OATP1B-mediated rifampicin interaction studies.

Yoshikado T, Aoki Y, Mochizuki T, Rodrigues AD, Chiba K, Kusuhara H, Sugiyama Y. Yoshikado T, et al. Among authors: mochizuki t. CPT Pharmacometrics Syst Pharmacol. 2022 Oct;11(10):1341-1357. doi: 10.1002/psp4.12849. Epub 2022 Aug 9. CPT Pharmacometrics Syst Pharmacol. 2022. PMID: 35945914 Free PMC article.

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