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FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD.
Fujino Y, Ueyama M, Ishiguro T, Ozawa D, Ito H, Sugiki T, Murata A, Ishiguro A, Gendron T, Mori K, Tokuda E, Taminato T, Konno T, Koyama A, Kawabe Y, Takeuchi T, Furukawa Y, Fujiwara T, Ikeda M, Mizuno T, Mochizuki H, Mizusawa H, Wada K, Ishikawa K, Onodera O, Nakatani K, Petrucelli L, Taguchi H, Nagai Y. Fujino Y, et al. Among authors: mochizuki h. Elife. 2023 Jul 18;12:RP84338. doi: 10.7554/eLife.84338. Elife. 2023. PMID: 37461319 Free PMC article.
Sustained therapeutic benefits by transient reduction of TDP-43 using ENA-modified antisense oligonucleotides in ALS/FTD mice.
Takeuchi T, Maeta K, Ding X, Oe Y, Takeda A, Inoue M, Nagano S, Fujihara T, Matsuda S, Ishigaki S, Sahashi K, Minakawa EN, Mochizuki H, Neya M, Sobue G, Nagai Y. Takeuchi T, et al. Among authors: mochizuki h. Mol Ther Nucleic Acids. 2023 Jan 16;31:353-366. doi: 10.1016/j.omtn.2023.01.006. eCollection 2023 Mar 14. Mol Ther Nucleic Acids. 2023. PMID: 36817728 Free PMC article.
A heterozygous splicing variant IVS9-7A > T in intron 9 of the MAPT gene in a patient with right-temporal variant frontotemporal dementia with atypical 4 repeat tauopathy.
Mori K, Shigenobu K, Beck G, Uozumi R, Satake Y, Suzuki M, Kondo S, Gotoh S, Yonenobu Y, Kawai M, Suzuki Y, Saito Y, Morii E, Hasegawa M, Mochizuki H, Murayama S, Ikeda M. Mori K, et al. Among authors: mochizuki h. Acta Neuropathol Commun. 2023 Aug 10;11(1):130. doi: 10.1186/s40478-023-01629-3. Acta Neuropathol Commun. 2023. PMID: 37563653 Free PMC article.
Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.
Ueda T, Takeuchi T, Fujikake N, Suzuki M, Minakawa EN, Ueyama M, Fujino Y, Kimura N, Nagano S, Yokoseki A, Onodera O, Mochizuki H, Mizuno T, Wada K, Nagai Y. Ueda T, et al. Among authors: mochizuki h. Acta Neuropathol Commun. 2024 Feb 4;12(1):20. doi: 10.1186/s40478-024-01729-8. Acta Neuropathol Commun. 2024. PMID: 38311779 Free PMC article.
Age-dependent decline in remyelination capacity is mediated by apelin-APJ signaling.
Ito M, Muramatsu R, Kato Y, Sharma B, Uyeda A, Tanabe S, Fujimura H, Kidoya H, Takakura N, Kawahara Y, Takao M, Mochizuki H, Fukamizu A, Yamashita T. Ito M, et al. Among authors: mochizuki h. Nat Aging. 2021 Mar;1(3):284-294. doi: 10.1038/s43587-021-00041-7. Epub 2021 Mar 15. Nat Aging. 2021. PMID: 37118408
Effects of COVID-19 pandemic-associated reduction in respiratory infections on infantile asthma development.
Kaiga C, Miyamoto M, Matsushita T, Kuramochi Y, Tadaki H, Enseki M, Hirai K, Yoshihara S, Furuya H, Niimura F, Kato M, Mochizuki H. Kaiga C, et al. Among authors: mochizuki h. J Allergy Clin Immunol Glob. 2024 Apr 11;3(3):100256. doi: 10.1016/j.jacig.2024.100256. eCollection 2024 Aug. J Allergy Clin Immunol Glob. 2024. PMID: 38745864 Free PMC article.
Effects of local reduction of endogenous α-synuclein using antisense oligonucleotides on the fibril-induced propagation of pathology through the neural network in wild-type mice.
Sano T, Nagata T, Ebihara S, Yoshida-Tanaka K, Nakamura A, Sasaki A, Shimozawa A, Mochizuki H, Uchihara T, Hasegawa M, Yokota T. Sano T, et al. Among authors: mochizuki h. Acta Neuropathol Commun. 2024 May 14;12(1):75. doi: 10.1186/s40478-024-01766-3. Acta Neuropathol Commun. 2024. PMID: 38745295
1,699 results