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Phosphatidylinositol-3,4,5-trisphosphate interacts with alpha-synuclein and initiates its aggregation and formation of Parkinson's disease-related fibril polymorphism.
Choong CJ, Aguirre C, Kakuda K, Beck G, Nakanishi H, Kimura Y, Shimma S, Nabekura K, Hideshima M, Doi J, Yamaguchi K, Nakajima K, Wadayama T, Hayakawa H, Baba K, Ogawa K, Takeuchi T, Badawy SMM, Murayama S, Nagano S, Goto Y, Miyanoiri Y, Nagai Y, Mochizuki H, Ikenaka K. Choong CJ, et al. Among authors: mochizuki h. Acta Neuropathol. 2023 May;145(5):573-595. doi: 10.1007/s00401-023-02555-3. Epub 2023 Mar 20. Acta Neuropathol. 2023. PMID: 36939875 Free PMC article.
Extracellular transportation of α-synuclein by HLA class II molecules.
Ozono T, Kimura Y, Suenaga T, Beck G, Jinno J, Aguirre C, Ikenaka K, Krainc D, Mochizuki H, Arase H. Ozono T, et al. Among authors: mochizuki h. Biochem Biophys Res Commun. 2023 Feb 12;644:25-33. doi: 10.1016/j.bbrc.2022.12.082. Epub 2022 Dec 31. Biochem Biophys Res Commun. 2023. PMID: 36621149
Human induced pluripotent stem cell line (ONHi001-A) generated from a patient with infantile neuroaxonal dystrophy having PLA2G6 c.517C > T (p.Q173X) and c.1634A > G (p.K545R) compound heterozygous mutations.
Fukusumi H, Togo K, Beck G, Shofuda T, Kanematsu D, Yamamoto A, Sumida M, Baba K, Mochizuki H, Kanemura Y. Fukusumi H, et al. Among authors: mochizuki h. Stem Cell Res. 2023 Jun;69:103122. doi: 10.1016/j.scr.2023.103122. Epub 2023 May 12. Stem Cell Res. 2023. PMID: 37209469 Free article.
RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.
Shimizu M, Shiraishi N, Tada S, Sasaki T, Beck G, Nagano S, Kinoshita M, Sumi H, Sugimoto T, Ishida Y, Koda T, Ishikura T, Sugiyama Y, Kihara K, Kanakura M, Nakajima T, Takeda S, Takahashi MP, Yamashita T, Okuno T, Mochizuki H. Shimizu M, et al. Among authors: mochizuki h. Sci Adv. 2023 Nov 24;9(47):eadg3193. doi: 10.1126/sciadv.adg3193. Epub 2023 Nov 22. Sci Adv. 2023. PMID: 37992159 Free PMC article.
Involvement of Mitochondria in Parkinson's Disease.
Choong CJ, Mochizuki H. Choong CJ, et al. Among authors: mochizuki h. Int J Mol Sci. 2023 Dec 1;24(23):17027. doi: 10.3390/ijms242317027. Int J Mol Sci. 2023. PMID: 38069350 Free PMC article. Review.
1,699 results