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Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.
Brown KM, Nair JK, Janas MM, Anglero-Rodriguez YI, Dang LTH, Peng H, Theile CS, Castellanos-Rizaldos E, Brown C, Foster D, Kurz J, Allen J, Maganti R, Li J, Matsuda S, Stricos M, Chickering T, Jung M, Wassarman K, Rollins J, Woods L, Kelin A, Guenther DC, Mobley MW, Petrulis J, McDougall R, Racie T, Bombardier J, Cha D, Agarwal S, Johnson L, Jiang Y, Lentini S, Gilbert J, Nguyen T, Chigas S, LeBlanc S, Poreci U, Kasper A, Rogers AB, Chong S, Davis W, Sutherland JE, Castoreno A, Milstein S, Schlegel MK, Zlatev I, Charisse K, Keating M, Manoharan M, Fitzgerald K, Wu JT, Maier MA, Jadhav V. Brown KM, et al. Among authors: mobley mw. Nat Biotechnol. 2022 Oct;40(10):1500-1508. doi: 10.1038/s41587-022-01334-x. Epub 2022 Jun 2. Nat Biotechnol. 2022. PMID: 35654979
17β-estradiol and tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice.
Sheh A, Ge Z, Parry NM, Muthupalani S, Rager JE, Raczynski AR, Mobley MW, McCabe AF, Fry RC, Wang TC, Fox JG. Sheh A, et al. Among authors: mobley mw. Cancer Prev Res (Phila). 2011 Sep;4(9):1426-35. doi: 10.1158/1940-6207.CAPR-11-0219. Epub 2011 Jun 16. Cancer Prev Res (Phila). 2011. PMID: 21680705 Free PMC article.
Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer.
Mangerich A, Knutson CG, Parry NM, Muthupalani S, Ye W, Prestwich E, Cui L, McFaline JL, Mobley M, Ge Z, Taghizadeh K, Wishnok JS, Wogan GN, Fox JG, Tannenbaum SR, Dedon PC. Mangerich A, et al. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1820-9. doi: 10.1073/pnas.1207829109. Epub 2012 Jun 11. Proc Natl Acad Sci U S A. 2012. PMID: 22689960 Free PMC article.
Systemic macrophage depletion inhibits Helicobacter bilis-induced proinflammatory cytokine-mediated typhlocolitis and impairs bacterial colonization dynamics in a BALB/c Rag2-/- mouse model of inflammatory bowel disease.
Muthupalani S, Ge Z, Feng Y, Rickman B, Mobley M, McCabe A, Van Rooijen N, Fox JG. Muthupalani S, et al. Infect Immun. 2012 Dec;80(12):4388-97. doi: 10.1128/IAI.00530-12. Epub 2012 Oct 1. Infect Immun. 2012. PMID: 23027534 Free PMC article.
12 results