LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes.
Elayyan J, Lee EJ, Gabay O, Smith CA, Qiq O, Reich E, Mobasheri A, Henrotin Y, Kimber SJ, Dvir-Ginzberg M.
Elayyan J, et al. Among authors: mobasheri a.
FASEB J. 2017 Jul;31(7):3116-3125. doi: 10.1096/fj.201601253R. Epub 2017 Apr 7.
FASEB J. 2017.
PMID: 28389425
Free article.
Conversely, MMP13 gene expression was reduced in chondrocytes transfected with SIRT1 siRNA or treated with nicotinamide (NAM), a sirtuin inhibitor. Chondrocytes challenged with IL-1beta, a cytokine involved in OA pathogenesis, enhanced LEF1 protein levels and gene e …
Conversely, MMP13 gene expression was reduced in chondrocytes transfected with SIRT1 siRNA or treated with nicotinamide (NAM), a sirt …