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Photochemical generation of 9H-fluorenyl radicals.
Dyblenko T, Chtchemelinine A, Reiter R, Chowdhury RQ, Enaya A, Afifi H, Fournier R, Mladenova G, Lever AB, Lee-Ruff E. Dyblenko T, et al. Among authors: mladenova g. Photochem Photobiol. 2014 Mar-Apr;90(2):470-5. doi: 10.1111/php.12225. Epub 2014 Jan 10. Photochem Photobiol. 2014. PMID: 24329554
Design, synthesis, and biological evaluation of 3,4-dihydroquinolin-2(1H)-one and 1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors.
Ramnauth J, Speed J, Maddaford SP, Dove P, Annedi SC, Renton P, Rakhit S, Andrews J, Silverman S, Mladenova G, Zinghini S, Nair S, Catalano C, Lee DK, De Felice M, Porreca F. Ramnauth J, et al. Among authors: mladenova g. J Med Chem. 2011 Aug 11;54(15):5562-75. doi: 10.1021/jm200648s. Epub 2011 Jul 8. J Med Chem. 2011. PMID: 21699209 Free PMC article.
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
Annedi SC, Maddaford SP, Mladenova G, Ramnauth J, Rakhit S, Andrews JS, Lee DK, Zhang D, Porreca F, Bunton D, Christie L. Annedi SC, et al. Among authors: mladenova g. J Med Chem. 2011 Oct 27;54(20):7408-16. doi: 10.1021/jm201063u. Epub 2011 Oct 5. J Med Chem. 2011. PMID: 21923116
Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.
Annedi SC, Ramnauth J, Maddaford SP, Renton P, Rakhit S, Mladenova G, Dove P, Silverman S, Andrews JS, Felice MD, Porreca F. Annedi SC, et al. Among authors: mladenova g. J Med Chem. 2012 Jan 26;55(2):943-55. doi: 10.1021/jm201564u. Epub 2012 Jan 10. J Med Chem. 2012. PMID: 22175766
1,2,3,4-tetrahydroquinoline-based selective human neuronal nitric oxide synthase (nNOS) inhibitors: lead optimization studies resulting in the identification of N-(1-(2-(methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a preclinical development candidate.
Ramnauth J, Renton P, Dove P, Annedi SC, Speed J, Silverman S, Mladenova G, Maddaford SP, Zinghini S, Rakhit S, Andrews J, Lee DK, Zhang D, Porreca F. Ramnauth J, et al. Among authors: mladenova g. J Med Chem. 2012 Mar 22;55(6):2882-93. doi: 10.1021/jm3000449. Epub 2012 Mar 1. J Med Chem. 2012. PMID: 22335555
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