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Extracellular aaRSs drive autoimmune and inflammatory responses in rheumatoid arthritis via the release of cytokines and PAD4.
Kimura A, Takagi T, Thamamongood T, Sakamoto S, Ito T, Seki I, Okamoto M, Aono H, Serada S, Naka T, Imataka H, Miyake K, Ueda T, Miyanokoshi M, Wakasugi K, Iwamoto N, Ohmagari N, Iguchi T, Nitta T, Takayanagi H, Yamashita H, Kaneko H, Tsuchiya H, Fujio K, Handa H, Suzuki H. Kimura A, et al. Among authors: miyake k. Ann Rheum Dis. 2023 Sep;82(9):1153-1161. doi: 10.1136/ard-2023-224055. Epub 2023 Jul 2. Ann Rheum Dis. 2023. PMID: 37400117
Inflammatory responses increase secretion of MD-1 protein.
Thomas Jennings R, Odkhuu E, Nakashima A, Morita N, Kobayashi T, Yamai I, Tanaka M, Suganami T, Haga S, Ozaki M, Watanabe Y, Nagai Y, Takatsu K, Kikuchi-Ueda T, Ichimonji I, Ogawa Y, Takagi H, Yamazaki T, Miyake K, Akashi-Takamura S. Thomas Jennings R, et al. Among authors: miyake k. Int Immunol. 2016 Oct;28(10):503-512. doi: 10.1093/intimm/dxw031. Epub 2016 Jun 28. Int Immunol. 2016. PMID: 27352793
C4b-binding protein negatively regulates TLR4/MD-2 response but not TLR3 response.
Morita N, Yamazaki T, Murakami Y, Fukui R, Yamai I, Ichimonji I, Nakashima A, Nagaoka F, Takagi H, Miyake K, Akashi-Takamura S. Morita N, et al. Among authors: miyake k. FEBS Lett. 2017 Jun;591(12):1732-1741. doi: 10.1002/1873-3468.12693. Epub 2017 Jun 12. FEBS Lett. 2017. PMID: 28542817 Free article.
Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex.
Okamoto N, Mizote K, Honda H, Saeki A, Watanabe Y, Yamaguchi-Miyamoto T, Fukui R, Tanimura N, Motoi Y, Akashi-Takamura S, Kato T, Fujishita S, Kimura T, Ohto U, Shimizu T, Hirokawa T, Miyake K, Fukase K, Fujimoto Y, Nagai Y, Takatsu K. Okamoto N, et al. Among authors: miyake k. J Biol Chem. 2017 Sep 15;292(37):15378-15394. doi: 10.1074/jbc.M117.791780. Epub 2017 Jul 28. J Biol Chem. 2017. PMID: 28754693 Free PMC article.
2,022 results