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A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice.
Yamazaki Y, Yasuda K, Matsuyama T, Ishihara T, Higa R, Sawairi T, Yamaguchi M, Egi M, Akai S, Miyase T, Ikari A, Miwa M, Sugatani J. Yamazaki Y, et al. Among authors: miwa m. Biochem Pharmacol. 2013 Sep 1;86(5):632-44. doi: 10.1016/j.bcp.2013.06.021. Epub 2013 Jun 28. Biochem Pharmacol. 2013. PMID: 23817078
A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation.
Yamaguchi M, Matsui M, Higa R, Yamazaki Y, Ikari A, Miyake M, Miwa M, Ishii S, Sugatani J, Shimizu T. Yamaguchi M, et al. Among authors: miwa m. Biochem Pharmacol. 2015 Feb 15;93(4):482-95. doi: 10.1016/j.bcp.2014.12.022. Epub 2015 Jan 8. Biochem Pharmacol. 2015. PMID: 25577975
Tea polyphenols inhibit acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and platelet-activating factor-induced platelet aggregation.
Sugatani J, Fukazawa N, Ujihara K, Yoshinari K, Abe I, Noguchi H, Miwa M. Sugatani J, et al. Among authors: miwa m. Int Arch Allergy Immunol. 2004 May;134(1):17-28. doi: 10.1159/000077529. Epub 2004 Mar 25. Int Arch Allergy Immunol. 2004. PMID: 15051936
803 results