Mitsuya H - Search Results

1

Pharmacokinetics studies of 4'-cyano-2'-deoxyguanosine, a potent inhibitor of the hepatitis B virus, in rats.

Hashimoto M, Taguchi K, Ishiguro T, Kohgo S, Imoto S, Yamasaki K, Mitsuya H, Otagiri M. Hashimoto M, et al. Among authors: mitsuya h. J Pharm Pharmacol. 2018 Jun;70(6):723-731. doi: 10.1111/jphp.12897. Epub 2018 Mar 12. J Pharm Pharmacol. 2018. PMID: 29528116 Free PMC article.

2

Antiretroviral chemotherapy against human immunodeficiency virus (hiv) infection: perspective for therapy of hepatitis B virus infection.

Mitsuya H, Broder S. Mitsuya H, et al. Cancer Detect Prev. 1989;14(2):299-308. Cancer Detect Prev. 1989. PMID: 2695248 Review.

3

4'-Ethynyl nucleoside analogs: potent inhibitors of multidrug-resistant human immunodeficiency virus variants in vitro.

Kodama EI, Kohgo S, Kitano K, Machida H, Gatanaga H, Shigeta S, Matsuoka M, Ohrui H, Mitsuya H. Kodama EI, et al. Among authors: mitsuya h. Antimicrob Agents Chemother. 2001 May;45(5):1539-46. doi: 10.1128/AAC.45.5.1539-1546.2001. Antimicrob Agents Chemother. 2001. PMID: 11302824 Free PMC article.

4

Synthesis of the L-enantiomer of 4'-C-ethynyl-2'-deoxycytidine.

Kohgo S, Mitsuya H, Ohrui H. Kohgo S, et al. Among authors: mitsuya h. Biosci Biotechnol Biochem. 2001 Aug;65(8):1879-82. doi: 10.1271/bbb.65.1879. Biosci Biotechnol Biochem. 2001. PMID: 11577734 Free article.

5

Synthesis of 4'-C-ethynyl and 4'-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity.

Kohgo S, Yamada K, Kitano K, Sakata S, Hayakawa H, Nameki D, Kodama E, Matsuoka M, Mitsuya H, Ohrui H. Kohgo S, et al. Among authors: mitsuya h. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):887-9. doi: 10.1081/NCN-120022678. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565303

6

Design, efficient synthesis, and anti-HIV activity of 4'-C-cyano- and 4'-C-ethynyl-2'-deoxy purine nucleosides.

Kohgo S, Yamada K, Kitano K, Iwai Y, Sakata S, Ashida N, Hayakawa H, Nameki D, Kodama E, Matsuoka M, Mitsuya H, Ohrui H. Kohgo S, et al. Among authors: mitsuya h. Nucleosides Nucleotides Nucleic Acids. 2004;23(4):671-90. doi: 10.1081/NCN-120037508. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15200030

7

Attempt to reduce cytotoxicity by synthesizing the L-enantiomer of 4'-C-ethynyl-2'-deoxypurine nucleosides as antiviral agents against HIV and HBV.

Kitano K, Kohgo S, Yamada K, Sakata S, Ashida N, Hayakawa H, Nameki D, Kodama E, Matsuoka M, Mitsuya H, Ohrui H. Kitano K, et al. Among authors: mitsuya h. Antivir Chem Chemother. 2004 May;15(3):161-7. doi: 10.1177/095632020401500306. Antivir Chem Chemother. 2004. PMID: 15266898 Free article.

8

Potential of 4'-C-substituted nucleosides for the treatment of HIV-1.

Hayakawa H, Kohgo S, Kitano K, Ashida N, Kodama E, Mitsuya H, Ohrui H. Hayakawa H, et al. Among authors: mitsuya h. Antivir Chem Chemother. 2004 Jul;15(4):169-87. doi: 10.1177/095632020401500401. Antivir Chem Chemother. 2004. PMID: 15457679 Free article. Review.

9

Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.

Nakata H, Amano M, Koh Y, Kodama E, Yang G, Bailey CM, Kohgo S, Hayakawa H, Matsuoka M, Anderson KS, Cheng YC, Mitsuya H. Nakata H, et al. Among authors: mitsuya h. Antimicrob Agents Chemother. 2007 Aug;51(8):2701-8. doi: 10.1128/AAC.00277-07. Epub 2007 Jun 4. Antimicrob Agents Chemother. 2007. PMID: 17548498 Free PMC article.

10

2'-deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma.

Ohrui H, Kohgo S, Hayakawa H, Kodama E, Matsuoka M, Nakata T, Mitsuya H. Ohrui H, et al. Among authors: mitsuya h. Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1543-6. doi: 10.1080/15257770701545218. Nucleosides Nucleotides Nucleic Acids. 2007. PMID: 18066823

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