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Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling.
Utoh M, Suemizu H, Mitsui M, Kawano M, Toda A, Uehara S, Uno Y, Shimizu M, Sasaki E, Yamazaki H. Utoh M, et al. Among authors: mitsui m. Xenobiotica. 2016 Dec;46(12):1049-1055. doi: 10.3109/00498254.2016.1147102. Epub 2016 Feb 25. Xenobiotica. 2016. PMID: 26916082
Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling.
Kamimura H, Ito S, Chijiwa H, Okuzono T, Ishiguro T, Yamamoto Y, Nishinoaki S, Ninomiya SI, Mitsui M, Kalgutkar AS, Yamazaki H, Suemizu H. Kamimura H, et al. Among authors: mitsui m. Xenobiotica. 2017 May;47(5):382-393. doi: 10.1080/00498254.2016.1199063. Epub 2016 Jul 7. Xenobiotica. 2017. PMID: 27389028
175 results