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Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects.
Mitra J, Guerrero EN, Hegde PM, Liachko NF, Wang H, Vasquez V, Gao J, Pandey A, Taylor JP, Kraemer BC, Wu P, Boldogh I, Garruto RM, Mitra S, Rao KS, Hegde ML. Mitra J, et al. Among authors: mitra s. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4696-4705. doi: 10.1073/pnas.1818415116. Epub 2019 Feb 15. Proc Natl Acad Sci U S A. 2019. PMID: 30770445 Free PMC article.
The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: DOMINANT NEGATIVE FUNCTION OF THE CTD.
Hegde PM, Dutta A, Sengupta S, Mitra J, Adhikari S, Tomkinson AE, Li GM, Boldogh I, Hazra TK, Mitra S, Hegde ML. Hegde PM, et al. Among authors: mitra s, mitra j. J Biol Chem. 2015 Aug 21;290(34):20919-20933. doi: 10.1074/jbc.M115.642918. Epub 2015 Jul 1. J Biol Chem. 2015. PMID: 26134572 Free PMC article.
Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?
Wang H, Dharmalingam P, Vasquez V, Mitra J, Boldogh I, Rao KS, Kent TA, Mitra S, Hegde ML. Wang H, et al. Among authors: mitra s, mitra j. Mech Ageing Dev. 2017 Jan;161(Pt A):163-176. doi: 10.1016/j.mad.2016.09.005. Epub 2016 Sep 20. Mech Ageing Dev. 2017. PMID: 27663141 Free PMC article. Review.
Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress.
Sengupta S, Yang C, Hegde ML, Hegde PM, Mitra J, Pandey A, Dutta A, Datarwala AT, Bhakat KK, Mitra S. Sengupta S, et al. Among authors: mitra s, mitra j. DNA Repair (Amst). 2018 Jun-Jul;66-67:1-10. doi: 10.1016/j.dnarep.2018.04.001. Epub 2018 Apr 17. DNA Repair (Amst). 2018. PMID: 29698889 Free PMC article.
346 results