Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

1,115 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
Pyridazine-derived γ-secretase modulators.
Wan Z, Hall A, Jin Y, Xiang JN, Yang E, Eatherton A, Smith B, Yang G, Yu H, Wang J, Ye L, Lau LF, Yang T, Mitchell W, Cai W, Zhang X, Sang Y, Wang Y, Tong Z, Cheng Z, Hussain I, Elliott JD, Matsuoka Y. Wan Z, et al. Among authors: mitchell w. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4016-9. doi: 10.1016/j.bmcl.2011.04.143. Epub 2011 May 13. Bioorg Med Chem Lett. 2011. PMID: 21636276
Pyridine-derived γ-secretase modulators.
Wan Z, Hall A, Sang Y, Xiang JN, Yang E, Smith B, Harrison DC, Yang G, Yu H, Price HS, Wang J, Hawkins J, Lau LF, Johnson MR, Li T, Zhao W, Mitchell WL, Su X, Zhang X, Zhou Y, Jin Y, Tong Z, Cheng Z, Hussain I, Elliott JD, Matsuoka Y. Wan Z, et al. Among authors: mitchell wl. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4832-5. doi: 10.1016/j.bmcl.2011.06.042. Epub 2011 Jun 17. Bioorg Med Chem Lett. 2011. PMID: 21742495
Orally bioavailable and brain-penetrant pyridazine and pyridine-derived γ-secretase modulators reduced amyloidogenic Aβ peptides in vivo.
Huang Y, Li T, Eatherton A, Mitchell WL, Rong N, Ye L, Yang XJ, Jin S, Ding Y, Zhang J, Li Y, Wu Y, Jin Y, Sang Y, Cheng Z, Browne ER, Harrison DC, Hussain I, Wan Z, Hall A, Lau LF, Matsuoka Y. Huang Y, et al. Neuropharmacology. 2013 Jul;70:278-86. doi: 10.1016/j.neuropharm.2013.02.003. Epub 2013 Feb 26. Neuropharmacology. 2013. PMID: 23485401
Pyridine-3-carboxamides as novel CB(2) agonists for analgesia.
Mitchell WL, Giblin GM, Naylor A, Eatherton AJ, Slingsby BP, Rawlings AD, Jandu KS, Haslam CP, Brown AJ, Goldsmith P, Clayton NM, Wilson AW, Chessell IP, Green RH, Whittington AR, Wall ID. Mitchell WL, et al. Bioorg Med Chem Lett. 2009 Jan 1;19(1):259-63. doi: 10.1016/j.bmcl.2008.10.118. Epub 2008 Nov 5. Bioorg Med Chem Lett. 2009. PMID: 19010671
Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain.
Giblin GM, Billinton A, Briggs M, Brown AJ, Chessell IP, Clayton NM, Eatherton AJ, Goldsmith P, Haslam C, Johnson MR, Mitchell WL, Naylor A, Perboni A, Slingsby BP, Wilson AW. Giblin GM, et al. Among authors: mitchell wl. J Med Chem. 2009 Oct 8;52(19):5785-8. doi: 10.1021/jm9009857. J Med Chem. 2009. PMID: 19743867
Discovery of 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain.
Giblin GM, O'Shaughnessy CT, Naylor A, Mitchell WL, Eatherton AJ, Slingsby BP, Rawlings DA, Goldsmith P, Brown AJ, Haslam CP, Clayton NM, Wilson AW, Chessell IP, Wittington AR, Green R. Giblin GM, et al. Among authors: mitchell wl. J Med Chem. 2007 May 31;50(11):2597-600. doi: 10.1021/jm061195+. Epub 2007 May 4. J Med Chem. 2007. PMID: 17477516
Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB(2) agonists for the treatment of inflammatory pain.
Gleave RJ, Beswick PJ, Brown AJ, Giblin GM, Goldsmith P, Haslam CP, Mitchell WL, Nicholson NH, Page LW, Patel S, Roomans S, Slingsby BP, Swarbrick ME. Gleave RJ, et al. Among authors: mitchell wl. Bioorg Med Chem Lett. 2010 Jan 15;20(2):465-8. doi: 10.1016/j.bmcl.2009.11.117. Epub 2009 Nov 27. Bioorg Med Chem Lett. 2010. PMID: 20005703
Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease.
Toledo-Sherman LM, Prime ME, Mrzljak L, Beconi MG, Beresford A, Brookfield FA, Brown CJ, Cardaun I, Courtney SM, Dijkman U, Hamelin-Flegg E, Johnson PD, Kempf V, Lyons K, Matthews K, Mitchell WL, O'Connell C, Pena P, Powell K, Rassoulpour A, Reed L, Reindl W, Selvaratnam S, Friley WW, Weddell DA, Went NE, Wheelan P, Winkler C, Winkler D, Wityak J, Yarnold CJ, Yates D, Munoz-Sanjuan I, Dominguez C. Toledo-Sherman LM, et al. Among authors: mitchell wl. J Med Chem. 2015 Feb 12;58(3):1159-83. doi: 10.1021/jm501350y. Epub 2015 Jan 23. J Med Chem. 2015. PMID: 25590515
Thrombin inhibitors based on [5,5] trans-fused indane lactams.
Pass M, Abu-Rabie S, Baxter A, Conroy R, Coote SJ, Craven AP, Finch H, Hindley S, Kelly HA, Lowdon AW, McDonald E, Mitchell WL, Pegg NA, Procopiou PA, Ramsden NG, Thomas R, Walker DA, Watson NS, Jhoti H, Mooney CJ, Tang CM, Thomas PJ, Parry S, Patel C. Pass M, et al. Among authors: mitchell wl. Bioorg Med Chem Lett. 1999 Jun 21;9(12):1657-62. doi: 10.1016/s0960-894x(99)00244-9. Bioorg Med Chem Lett. 1999. PMID: 10397495
1,115 results