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Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents.
van den Driesche S, Walker M, McKinnell C, Scott HM, Eddie SL, Mitchell RT, Seckl JR, Drake AJ, Smith LB, Anderson RA, Sharpe RM. van den Driesche S, et al. Among authors: mitchell rt. PLoS One. 2012;7(5):e37064. doi: 10.1371/journal.pone.0037064. Epub 2012 May 17. PLoS One. 2012. PMID: 22615892 Free PMC article.
Intratubular germ cell neoplasia of the human testis: heterogeneous protein expression and relation to invasive potential.
Mitchell RT, Camacho-Moll M, Macdonald J, Anderson RA, Kelnar CJ, O'Donnell M, Sharpe RM, Smith LB, Grigor KM, Wallace WHB, Stoop H, Wolffenbuttel KP, Donat R, Saunders PT, Looijenga LH. Mitchell RT, et al. Mod Pathol. 2014 Sep;27(9):1255-1266. doi: 10.1038/modpathol.2013.246. Epub 2014 Jan 24. Mod Pathol. 2014. PMID: 24457464 Free PMC article.
Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis.
Rebourcet D, O'Shaughnessy PJ, Pitetti JL, Monteiro A, O'Hara L, Milne L, Tsai YT, Cruickshanks L, Riethmacher D, Guillou F, Mitchell RT, van't Hof R, Freeman TC, Nef S, Smith LB. Rebourcet D, et al. Among authors: mitchell rt. Development. 2014 May;141(10):2139-49. doi: 10.1242/dev.107029. Development. 2014. PMID: 24803659 Free PMC article.
Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late-onset Leydig cell apoptosis in both mice and men.
O'Hara L, McInnes K, Simitsidellis I, Morgan S, Atanassova N, Slowikowska-Hilczer J, Kula K, Szarras-Czapnik M, Milne L, Mitchell RT, Smith LB. O'Hara L, et al. Among authors: mitchell rt. FASEB J. 2015 Mar;29(3):894-910. doi: 10.1096/fj.14-255729. Epub 2014 Nov 17. FASEB J. 2015. PMID: 25404712 Free PMC article.
160 results